{"id":"W2763765527","doi":"10.1093/annonc/mdx380.047","title":"Intracranial efficacy of brigatinib (BRG) in patients (Pts) With crizotinib (CRZ)-refractory anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC) and baseline CNS metastases","year":2017,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Radiosurgery; Crizotinib; Brain metastasis; Anaplastic lymphoma kinase; Internal medicine; Lung cancer; Asymptomatic; Chemotherapy; Oncology; Cancer; Gastroenterology; Radiation therapy; Surgery; Metastasis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002041151,0.0003334768,0.0008422502,0.0001949547,0.0001328742,0.0004620923,0.0002845584,0.0003380977,0.001495541],"category_scores_gemma":[0.0006573165,0.0001688342,0.0004901701,0.0002030311,0.0002405851,0.0003625472,0.0001256035,0.001306862,0.0003408166],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005827884,"about_ca_system_score_gemma":0.0007182105,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002687544,"about_ca_topic_score_gemma":0.007031494,"domain_scores_codex":[0.9999262,0.0000199686,0.000005844753,0.00001134822,0.000009937102,0.00002667821],"domain_scores_gemma":[0.9998596,0.00003320145,0.00003763057,0.000008167642,0.000008268782,0.00005312224],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.5628411,0.005015392,0.03492428,0.001146325,0.001816493,0.001696607,0.0002374602,0.003165801,0.05132917,0.0004751467,0.01049639,0.3268557],"study_design_scores_gemma":[0.1916795,0.2658935,0.4811038,0.00038129,0.005477651,0.005324951,0.0004814064,0.009784778,0.01989066,0.0008495075,0.01895592,0.000176929],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923959,0.004625842,0.00005393637,0.0003487731,0.00009456086,0.00004532435,0.000361222,0.00004656049,0.002027897],"genre_scores_gemma":[0.9967997,0.001826658,0.0000832557,0.0001619254,0.00008971131,0.00002278264,0.0005313616,0.000006711001,0.0004779229],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002687544,"threshold_uncertainty_score":0.005343854,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02396518183955062,"score_gpt":0.3632289700416785,"score_spread":0.3392637882021279,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}