{"id":"W2763785504","doi":"10.1016/j.chom.2017.09.007","title":"GBPs Inhibit Motility of Shigella flexneri but Are Targeted for Degradation by the Bacterial Ubiquitin Ligase IpaH9.8","year":2017,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":198,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Medical Research Council; Institut Carnot Santé Animale; Boehringer Ingelheim Fonds; Wellcome Trust","keywords":"Shigella flexneri; Biology; Ubiquitin ligase; Motility; Shigella; Cytosol; Cell biology; Microbiology; Host–pathogen interaction; Ubiquitin; Immunity; Bacteria; Virulence; Biochemistry; Immunology; Immune system; Escherichia coli; Salmonella; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006073318,0.0002180936,0.000430107,0.00006376885,0.0004743822,0.0001399353,0.0004051609,0.0001844825,0.0005626385],"category_scores_gemma":[0.0002928909,0.000161981,0.0001999789,0.00007420554,0.0003230975,0.0001246784,0.0001981955,0.0003084854,0.00006494821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008819887,"about_ca_system_score_gemma":0.000198666,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008477413,"about_ca_topic_score_gemma":0.0002246881,"domain_scores_codex":[0.9984264,0.00006586155,0.00041711,0.0003882835,0.000254979,0.0004473927],"domain_scores_gemma":[0.9980881,0.0001166387,0.0003564521,0.0009627852,0.0003054971,0.0001705266],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008096271,0.0002720697,0.00236915,0.0002948252,0.00003285089,0.000006204809,0.00019419,1.921928e-7,0.9551686,0.00001178056,0.03834819,0.002492288],"study_design_scores_gemma":[0.002141906,0.0001949164,0.0110708,0.00008373493,0.00006043544,0.000005416563,0.0001627292,0.00004920269,0.8644397,0.00002040596,0.1216462,0.0001245013],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938719,0.0005821945,0.00009221824,0.00166321,0.0002431096,0.001140946,0.001103066,0.00002872313,0.001274639],"genre_scores_gemma":[0.9907525,0.0001254331,0.0002531165,0.0002200872,0.000340258,0.00004829891,0.0003925333,0.00004412547,0.007823609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09072892,"threshold_uncertainty_score":0.6605393,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03224944099033471,"score_gpt":0.3063760864776054,"score_spread":0.2741266454872707,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}