{"id":"W2763785504","doi":"10.1016/j.chom.2017.09.007","title":"GBPs Inhibit Motility of Shigella flexneri but Are Targeted for Degradation by the Bacterial Ubiquitin Ligase IpaH9.8","year":2017,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":198,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Medical Research Council; Institut Carnot Santé Animale; Boehringer Ingelheim Fonds; Wellcome Trust","keywords":"Shigella flexneri; Biology; Ubiquitin ligase; Motility; Shigella; Cytosol; Cell biology; Microbiology; Host–pathogen interaction; Ubiquitin; Immunity; Bacteria; Virulence; Biochemistry; Immunology; Immune system; Escherichia coli; Salmonella; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007614575,0.0003259454,0.0001573968,0.00008663321,0.00008685573,0.0001173264,0.0000870407,0.0001625919,0.001294017],"category_scores_gemma":[0.00007341702,0.00007033766,0.0001920824,0.00004654825,0.0001413701,0.0001320827,0.0001706157,0.0003519311,0.0003119882],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001380887,"about_ca_system_score_gemma":0.0001107981,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003848847,"about_ca_topic_score_gemma":0.0007571587,"domain_scores_codex":[0.9999411,0.0000107923,0.000004156836,0.000007414022,0.00001513452,0.00002140377],"domain_scores_gemma":[0.9999669,0.000006066201,0.000009352229,0.00000530757,0.000004548763,0.00000793155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001576439,0.00002623217,0.0002392806,0.00003186261,0.000006296256,0.00002725738,0.000004874849,0.00005198158,0.9964995,0.00005678629,0.00005593006,0.002842296],"study_design_scores_gemma":[0.0000175353,0.0004817671,0.005137107,0.000004455957,0.000008689093,0.000142616,0.0000141248,0.0004238257,0.9921049,0.0000451845,0.001618102,0.000001855439],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917808,0.003661983,0.001653718,0.0002032589,0.00005297614,0.00001710038,0.0001683792,0.00006472809,0.002397005],"genre_scores_gemma":[0.9955117,0.001092606,0.0009335484,0.00004769925,0.000008386577,0.00001321005,0.0001683975,0.000009345042,0.002215145],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001294017,"threshold_uncertainty_score":0.004328907,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03224944099033471,"score_gpt":0.3063760864776054,"score_spread":0.2741266454872707,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}