{"id":"W2763937928","doi":"","title":"Investigation of Amorphous Solid Dispersions of Poorly Water-soluble Drugs in Poly (2-hydroxyethyl Methacrylate) Hydrogels for Enhanced Solubility and Controlled Release","year":2014,"lang":"en","type":"dissertation","venue":"TSpace (University of Toronto)","topic":"Drug Solubulity and Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; University of Toronto","keywords":"2-Hydroxyethyl Methacrylate; Self-healing hydrogels; Solubility; Methacrylate; Amorphous solid; Materials science; Chemical engineering; Polymer chemistry; (Hydroxyethyl)methacrylate; Chemistry; Polymer; Organic chemistry; Composite material; Copolymer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001426122,0.0003459791,0.001483391,0.0001651098,0.0001960151,0.000005126718,0.0003590142,0.0008604479,0.001214071],"category_scores_gemma":[0.0001100442,0.0003755076,0.0003718957,0.00008789504,0.0004043239,0.0003174694,0.00007585969,0.0003887424,0.000005393475],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001966944,"about_ca_system_score_gemma":0.0002057083,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.06528961,"about_ca_topic_score_gemma":0.04923574,"domain_scores_codex":[0.99751,0.0007167637,0.0006061005,0.0005000696,0.0002566578,0.0004103754],"domain_scores_gemma":[0.9974859,0.0006459067,0.0009297982,0.0003344608,0.0003680864,0.0002358844],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.03118991,0.0007478676,0.002379646,0.005123993,0.001646754,0.00000866774,0.1771092,0.0007005375,0.7675855,0.0006187158,0.0004919453,0.01239728],"study_design_scores_gemma":[0.0403411,0.001913153,0.02820545,0.0009262645,0.003272577,0.000003848743,0.07600247,0.02775363,0.8180709,0.0008049998,0.001183575,0.001522001],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915954,0.001474756,0.0002713924,0.0002168566,0.0006866288,0.00154532,0.0001503535,0.00003251239,0.004026817],"genre_scores_gemma":[0.99366,0.0004408838,0.0003136699,0.00002948862,0.00003660352,0.00000879172,0.0003523051,0.00002642924,0.005131772],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1011067,"threshold_uncertainty_score":0.9998697,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03451998457747747,"score_gpt":0.3371056137555571,"score_spread":0.3025856291780796,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}