{"id":"W2763979809","doi":"10.1016/j.cell.2017.09.019","title":"Lactate Metabolism in Human Lung Tumors","year":2017,"lang":"en","type":"article","venue":"Cell","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1320,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Cancer Institute; National Institutes of Health; University of Texas Southwestern Medical Center; National Institute of Diabetes and Digestive and Kidney Diseases; American Lung Association; V Foundation for Cancer Research; National Center for Advancing Translational Sciences; Agios Pharmaceuticals; Welch Foundation; Howard Hughes Medical Institute","keywords":"Biology; Citric acid cycle; In vivo; Metabolism; Tricarboxylic acid; Glycolysis; Biochemistry; Lactate dehydrogenase; Metabolite; Carbohydrate metabolism; Internal medicine; Endocrinology; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000144313,0.0001593519,0.0001987083,0.0004954585,0.0002425913,0.0004702124,0.0001254208,0.0001736719,0.001284329],"category_scores_gemma":[0.0001785963,0.0001180629,0.0001215669,0.0005010993,0.0001981317,0.0002101909,0.0001678124,0.0001999848,0.0002416176],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003341164,"about_ca_system_score_gemma":0.0002990182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00622479,"about_ca_topic_score_gemma":0.003788996,"domain_scores_codex":[0.9999107,0.00002540508,0.00000579365,0.00001444701,0.00002054225,0.00002313966],"domain_scores_gemma":[0.9999421,0.00001504613,0.000009524243,0.000006949682,0.00001279506,0.00001361751],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006564206,0.0001134378,0.03482587,0.0001860694,0.00006748449,0.001276369,0.0005402635,0.0006654183,0.9327288,0.001151811,0.0005728222,0.02130751],"study_design_scores_gemma":[0.0001815095,0.00124202,0.2377304,0.00003918932,0.000167564,0.003574042,0.001410056,0.00351391,0.7351294,0.00114996,0.01582845,0.00003359616],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986806,0.009088645,0.001065641,0.0002147462,0.0000321567,0.0000185281,0.0007197513,0.00003093264,0.002023666],"genre_scores_gemma":[0.9942217,0.002304395,0.000308052,0.00003432149,0.0000104152,0.00001331542,0.0008873751,0.000007376089,0.002213039],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00622479,"threshold_uncertainty_score":0.01237708,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009696924788127833,"score_gpt":0.2619342706481667,"score_spread":0.2522373458600389,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}