{"id":"W2763994899","doi":"10.1681/asn.2017030285","title":"ShcA Adaptor Protein Promotes Nephrin Endocytosis and Is Upregulated in Proteinuric Nephropathies","year":2017,"lang":"en","type":"article","venue":"Journal of the American Society of Nephrology","topic":"Renal Diseases and Glomerulopathies","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; McGill University Health Centre; University of Guelph","funders":"Canadian Institutes of Health Research","keywords":"Nephrin; Slit diaphragm; Podocyte; Endocytic cycle; Cell biology; Phosphorylation; Downregulation and upregulation; Immunoprecipitation; Tyrosine phosphorylation; Proto-oncogene tyrosine-protein kinase Src; Signal transducing adaptor protein; Biology; Cancer research; Endocytosis; Endocrinology; Kidney; Cell; Biochemistry; Proteinuria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001168263,0.0002376183,0.0002383516,0.000561605,0.0002882511,0.0003084948,0.0001130521,0.0002966936,0.001536839],"category_scores_gemma":[0.0001908623,0.0001740064,0.0003215874,0.0002824945,0.0002893087,0.0001740471,0.0003299567,0.0003244272,0.0002206024],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002007693,"about_ca_system_score_gemma":0.0001629779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005319539,"about_ca_topic_score_gemma":0.000474477,"domain_scores_codex":[0.9998846,0.00001399481,0.00001052641,0.00002231388,0.00003588499,0.00003267135],"domain_scores_gemma":[0.9998153,0.00001324941,0.00005994879,0.00001363762,0.000026287,0.00007160671],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007417478,0.00003878768,0.01165222,0.00006218674,0.000039507,0.0006841719,0.0000519497,0.00005209998,0.9847376,0.0001255204,0.0001063569,0.001707827],"study_design_scores_gemma":[0.00006912313,0.0002803837,0.6115474,0.00001634591,0.0001477851,0.0025485,0.0002276643,0.002030469,0.3800455,0.0003153919,0.002755446,0.00001597237],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987037,0.0005391495,0.0003082667,0.00003541071,0.000009527519,0.000003381681,0.00006407081,0.00003184295,0.000304684],"genre_scores_gemma":[0.9987765,0.0001901128,0.0001956658,0.00001658751,0.00001118323,0.000008217366,0.00008810001,0.000006340232,0.0007073441],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001536839,"threshold_uncertainty_score":0.005141258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01646056965962643,"score_gpt":0.2767843054533358,"score_spread":0.2603237357937094,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}