{"id":"W2764046617","doi":"10.1186/s40168-017-0357-4","title":"Non-digestible oligosaccharides directly regulate host kinome to modulate host inflammatory responses without alterations in the gut microbiota","year":2017,"lang":"en","type":"article","venue":"Microbiome","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; McMaster University; Burman University; Hospital for Sick Children; SickKids Foundation; University of Toronto","funders":"Institute of Nutrition, Metabolism and Diabetes; Canadian Institutes of Health Research","keywords":"Kinome; Prebiotic; Biology; Immune system; Gut flora; Innate immune system; Lipopolysaccharide; Host (biology); Signal transduction; Microbiology; Inflammation; Immunology; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001035336,0.0003555455,0.0001511736,0.0001406048,0.0000855671,0.0002239181,0.00009673442,0.0001538533,0.001675984],"category_scores_gemma":[0.00009920787,0.00007825365,0.0001539258,0.00009225462,0.0001552824,0.000210665,0.0001929733,0.0003273508,0.000231369],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001828048,"about_ca_system_score_gemma":0.0001595765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001619811,"about_ca_topic_score_gemma":0.0003821848,"domain_scores_codex":[0.999921,0.00001456318,0.000004586109,0.00001763118,0.00002043622,0.00002192671],"domain_scores_gemma":[0.9999233,0.000009804458,0.0000284447,0.000006140789,0.00001243277,0.0000198339],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008747361,0.00001196102,0.0002792751,0.00002029352,0.000002161523,0.00001651265,0.000003899938,0.00001528783,0.9989173,0.00002597906,0.000008496425,0.0006113303],"study_design_scores_gemma":[0.00001138092,0.0004271857,0.02549994,0.000008797246,0.00001612537,0.0001305649,0.00004136165,0.0004986805,0.9720134,0.00009146567,0.001256829,0.00000418422],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938489,0.001413451,0.003108825,0.00008138033,0.00002181608,0.00003125993,0.0003171072,0.00003582037,0.00114152],"genre_scores_gemma":[0.9945251,0.0007407712,0.002617125,0.00008785779,0.000007808509,0.00003137073,0.0002486368,0.000009647344,0.001731753],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001675984,"threshold_uncertainty_score":0.005606771,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01467567123066642,"score_gpt":0.2856175217382336,"score_spread":0.2709418505075672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}