{"id":"W2764068477","doi":"10.1002/slct.201702025","title":"Copper‐Catalyzed Tandem Imine Formation, Sonogashira Coupling and Intramolecular Hydroamination: A Facile Synthesis of 3‐Aryl‐γ−carbolines","year":2017,"lang":"en","type":"article","venue":"ChemistrySelect","topic":"Synthesis and bioactivity of alkaloids","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nipissing University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Hydroamination; Sonogashira coupling; Imine; Intramolecular force; Aryl; Chemistry; Combinatorial chemistry; Catalysis; Copper; Coupling reaction; Amination; Organic chemistry; Medicinal chemistry; Palladium","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001753199,0.0004905335,0.0002878192,0.0002131616,0.0001583673,0.0001641704,0.0005448597,0.0002821874,0.0009638095],"category_scores_gemma":[0.0001606512,0.0002077622,0.0002384398,0.0001727919,0.000201302,0.000274252,0.0003528841,0.0004332931,0.0004990651],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002087113,"about_ca_system_score_gemma":0.0003030058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005503907,"about_ca_topic_score_gemma":0.001548563,"domain_scores_codex":[0.9998647,0.00002173791,0.00001247259,0.00003608122,0.00003196033,0.00003298936],"domain_scores_gemma":[0.9999264,0.000009206373,0.0000171568,0.00001405743,0.00001444098,0.00001870478],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006240051,0.0000410835,0.0001345639,0.0001717241,0.00002468787,0.0003487558,0.00007959947,0.0002368241,0.9889656,0.0004152462,0.0001214169,0.009398201],"study_design_scores_gemma":[0.00001626557,0.0002637858,0.0004919011,0.000006623692,0.00001946013,0.0003635787,0.00001644519,0.0004759092,0.9950783,0.00004399945,0.00321372,0.000009993724],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9516365,0.003545511,0.032022,0.0001046056,0.00007556316,0.0002916557,0.0003630122,0.0003802986,0.01158079],"genre_scores_gemma":[0.9806963,0.001336964,0.01459417,0.00002921563,0.00001160727,0.00008238206,0.0001623085,0.0000294838,0.003057624],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009638095,"threshold_uncertainty_score":0.003224254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01066087162317289,"score_gpt":0.240135838930875,"score_spread":0.2294749673077021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}