{"id":"W2764094032","doi":"10.1093/annonc/mdx372.062","title":"FORWARD I: A phase 3 study to evaluate the safety and efficacy of mirvetuximab soravtansine (IMGN853) versus chemotherapy in adults with folate receptor alpha (FRa)-positive, platinum-resistant epithelial ovarian cancer, primary peritoneal cancer, or primary fallopian tube cancer","year":2017,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Tolerability; Ovarian cancer; Internal medicine; Oncology; Clinical endpoint; Chemotherapy regimen; Cancer; Phases of clinical research; Topotecan; Chemotherapy; Clinical trial; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00190119,0.001753766,0.003307592,0.0005479995,0.0004911218,0.001136065,0.001064234,0.001667949,0.008033176],"category_scores_gemma":[0.001678322,0.0009152126,0.002905831,0.0004731044,0.001328076,0.001405406,0.0004452602,0.004961291,0.001426076],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00164087,"about_ca_system_score_gemma":0.002307086,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001603846,"about_ca_topic_score_gemma":0.004312437,"domain_scores_codex":[0.999483,0.0002191547,0.00002365009,0.0001132169,0.00005652924,0.0001045827],"domain_scores_gemma":[0.998892,0.0002327173,0.0002327373,0.0001164835,0.00007586323,0.000450197],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9023603,0.02842546,0.00231702,0.0005842336,0.001576235,0.0001024931,0.0001477981,0.001707017,0.01480181,0.0002778969,0.002710583,0.04498918],"study_design_scores_gemma":[0.6932791,0.2971582,0.004110237,0.00002938424,0.0006745828,0.0001239227,0.00003609886,0.0008832683,0.001732429,0.0002453494,0.001698299,0.00002916378],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863006,0.002543518,0.001070898,0.0008583501,0.0003372389,0.00357777,0.002474095,0.0002438841,0.002593664],"genre_scores_gemma":[0.9770516,0.002551658,0.004427967,0.00186833,0.0003489858,0.004162055,0.004053093,0.0001161073,0.005420369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008033176,"threshold_uncertainty_score":0.02687371,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05103716698847886,"score_gpt":0.3993897319209964,"score_spread":0.3483525649325175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}