{"id":"W2764162783","doi":"10.1038/nrneph.2017.129","title":"Endoplasmic reticulum stress, the unfolded protein response and autophagy in kidney diseases","year":2017,"lang":"en","type":"review","venue":"Nature Reviews Nephrology","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":522,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Unfolded protein response; Proteostasis; Endoplasmic reticulum; Medicine; Autophagy; Chemical chaperone; Podocyte; Kidney; Focal segmental glomerulosclerosis; Kidney disease; ATF6; Cancer research; Cell biology; Apoptosis; Internal medicine; Biology; Glomerulonephritis; Proteinuria; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0007959716,0.0008647779,0.002276805,0.0001619372,0.000243456,0.0001087107,0.001094694,0.001685214,0.00004370674],"category_scores_gemma":[0.003762509,0.000532546,0.0007302565,0.0001636509,0.0005806851,0.000009993715,0.0005668952,0.00134918,0.00003669933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003863044,"about_ca_system_score_gemma":0.0008649498,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000134755,"about_ca_topic_score_gemma":0.00005522661,"domain_scores_codex":[0.994616,0.002321698,0.000986089,0.001199276,0.0002104655,0.0006664593],"domain_scores_gemma":[0.9964709,0.0001765554,0.0009270504,0.001977365,0.00006273272,0.0003853764],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0009580377,0.0003238915,0.0002284283,0.02890561,0.0004582423,0.0005009537,0.00003023782,7.541537e-7,0.0004643388,0.0006808398,0.02823053,0.9392182],"study_design_scores_gemma":[0.0006265035,0.0001620645,0.0001505898,0.006971432,0.000618568,0.0001713984,0.000003345647,0.00000269775,0.0000712082,0.00008227448,0.990628,0.0005119412],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001453994,0.9937387,0.000001823719,0.0004457324,0.0002974164,0.003272551,0.0005354049,0.00001880846,0.0002356349],"genre_scores_gemma":[0.0006352206,0.994931,0.00006311124,0.001084894,0.000454204,0.001318826,0.0007204691,0.00008124349,0.0007109772],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9623975,"threshold_uncertainty_score":0.9997126,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02069925876928835,"score_gpt":0.3372679839554625,"score_spread":0.3165687251861741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}