{"id":"W2764229395","doi":"10.3390/ph10040079","title":"Orexin Receptor Multimerization versus Functional Interactions: Neuropharmacological Implications for Opioid and Cannabinoid Signalling and Pharmacogenetics","year":2017,"lang":"en","type":"article","venue":"Pharmaceuticals","topic":"Sleep and Wakefulness Research","field":"Neuroscience","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Magnus Ehrnroothin Säätiö; Scottish Rite Charitable Foundation of Canada; Canadian Institutes of Health Research; Ironwood Pharmaceuticals, Incorporated","keywords":"Pharmacogenetics; Cannabinoid receptor; Opioid; Cannabinoid; Pharmacology; Opioid receptor; Neuroscience; Medicine; Receptor; Computational biology; Biology; Gene; Genetics; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002082332,0.0001689426,0.000153634,0.00008334166,0.001290541,0.0002990792,0.0002285364,0.00005183071,0.0002909911],"category_scores_gemma":[0.001466863,0.0001583557,0.00004627324,0.00008433186,0.0004126746,0.0003218928,0.0002059553,0.0002480169,0.00002324426],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003249856,"about_ca_system_score_gemma":0.00004477043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000513285,"about_ca_topic_score_gemma":0.000001000404,"domain_scores_codex":[0.9985698,0.0001265001,0.000232696,0.0005381014,0.0001747846,0.0003581115],"domain_scores_gemma":[0.9982485,0.001031125,0.0001110311,0.0001842638,0.0001237351,0.0003013832],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006954534,0.0001090988,0.001874883,0.00002830374,0.0000208252,0.000001615237,0.00003848044,0.00004875906,0.923963,0.0009869154,0.0006146182,0.07161808],"study_design_scores_gemma":[0.005354426,0.0001814511,0.01068672,0.00001297465,0.00013512,0.000020705,0.00001974912,0.05072322,0.865177,0.0007428182,0.0665898,0.000355963],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9779594,0.0003239413,0.008921629,0.008843308,0.001593981,0.001396845,0.0002299614,0.0001159101,0.0006150365],"genre_scores_gemma":[0.9966452,0.001012175,0.0005841714,0.0007628467,0.0003543134,0.000434011,0.00001410842,0.00002554406,0.0001676607],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07126211,"threshold_uncertainty_score":0.9925932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2976740429152941,"score_gpt":0.4639264764572202,"score_spread":0.1662524335419261,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}