{"id":"W2764265682","doi":"10.1016/j.chembiol.2017.08.025","title":"Ras Binder Induces a Modified Switch-II Pocket in GTP and GDP States","year":2017,"lang":"en","type":"article","venue":"Cell chemical biology","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":117,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Victoria","funders":"National Institute of General Medical Sciences; National Institutes of Health; National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Cancer Research Society","keywords":"GTP'; Nucleotide; Guanine nucleotide exchange factor; Covalent bond; Molecular switch; Cysteine; Chemistry; Ligand (biochemistry); Allosteric regulation; Stereochemistry; GTPase; Biophysics; Biochemistry; Biology; Enzyme; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001358944,0.0001447993,0.0001715671,0.0000358052,0.0001298925,0.0000256922,0.0002003797,0.000312943,0.00002660653],"category_scores_gemma":[0.0001004865,0.0001272614,0.00004107645,0.000024336,0.0002231972,0.000004279197,0.0002916852,0.0001208255,0.00000419363],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008709811,"about_ca_system_score_gemma":0.00003236982,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006444028,"about_ca_topic_score_gemma":0.00001226919,"domain_scores_codex":[0.9991195,0.00003522813,0.0001778487,0.0003762133,0.00003966559,0.0002515176],"domain_scores_gemma":[0.9994479,0.00001325786,0.0001014925,0.0003188873,0.00003118861,0.00008726014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000064442,0.00004342763,0.001878261,0.0000140482,0.000009309713,0.000002706508,0.00003817619,0.000003504858,0.9960827,0.0001076273,0.0001719608,0.001583838],"study_design_scores_gemma":[0.0008840684,0.00008027222,0.0009089459,0.00001098168,0.000005320673,0.000005103253,0.00002539836,0.0001073029,0.9915364,0.00284897,0.003405608,0.0001815853],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971215,0.001283869,0.0001059729,0.0003667689,0.00005178276,0.0001237889,0.00001447194,0.000008274423,0.0009235997],"genre_scores_gemma":[0.9988586,0.0001575587,0.0002573674,0.0003094103,0.000111269,0.00001953385,0.0001278369,0.00001159817,0.0001467879],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004546254,"threshold_uncertainty_score":0.518957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01703194466567543,"score_gpt":0.2639201520717643,"score_spread":0.2468882074060889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}