{"id":"W2765080398","doi":"10.1016/j.celrep.2017.10.025","title":"Metaplasticity at CA1 Synapses by Homeostatic Control of Presynaptic Release Dynamics","year":2017,"lang":"en","type":"article","venue":"Cell Reports","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Government of Ontario","keywords":"Metaplasticity; Homeostatic plasticity; Neuroscience; Long-term potentiation; Synaptic plasticity; Postsynaptic potential; Neuronal memory allocation; Homeostasis; Glutamate receptor; Synaptic scaling; Synapse; Biology; Chemistry; Cell biology; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003386603,0.0001981295,0.0003667505,0.00009249298,0.0007394996,0.00009001814,0.0006190444,0.00007143885,0.0001370024],"category_scores_gemma":[0.004236394,0.0001733431,0.0001071211,0.0001123712,0.001157778,0.0002870189,0.0003366746,0.0002707898,0.00004327429],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006252553,"about_ca_system_score_gemma":0.0001219498,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000386328,"about_ca_topic_score_gemma":0.000007646406,"domain_scores_codex":[0.9974186,0.0002219115,0.0004726832,0.0007636404,0.0005837959,0.0005393517],"domain_scores_gemma":[0.9971671,0.0007693473,0.0007244124,0.001005927,0.00007472998,0.0002584925],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009524398,0.0002032719,0.007717792,0.00005844014,0.00000469323,0.003871334,0.00001856986,0.00004551134,0.9864755,0.00002456726,0.001315027,0.0001700209],"study_design_scores_gemma":[0.0004848574,0.0002069778,0.001738215,0.000009092186,0.00005329013,0.0004095108,0.000004691015,0.008456523,0.9878003,0.00008873552,0.0005883034,0.0001595323],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965003,0.00006710502,0.0001868769,0.0002448462,0.0006714909,0.0004468572,0.00006211174,0.00004376949,0.001776664],"genre_scores_gemma":[0.9943054,0.0001387795,0.000005634019,0.0003264791,0.00001734156,0.00002956268,0.000001258286,0.00002539519,0.005150179],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008411012,"threshold_uncertainty_score":0.7068725,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02561745801306028,"score_gpt":0.302295145564896,"score_spread":0.2766776875518357,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}