{"id":"W2765122733","doi":"10.1002/9781119092599.ch9","title":"Synthetic Strategies for Macrocyclic Peptides","year":2017,"lang":"en","type":"other","venue":"","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Chemistry; Cyclic peptide; Epimer; Peptide; Combinatorial chemistry; Reagent; Residue (chemistry); Disulfide bond; Stereochemistry; Peptide synthesis; Ring size; Ring (chemistry); Chemical synthesis; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004652064,0.0002054987,0.0002509561,0.00003391542,0.0000553262,0.00007545079,0.0003029658,0.0003198058,0.0006288496],"category_scores_gemma":[0.00005479066,0.0001631652,0.0002869699,0.00001030793,0.00008392178,7.464367e-7,0.0000653943,0.00003820106,0.00003088419],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004159884,"about_ca_system_score_gemma":0.00003785929,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001116382,"about_ca_topic_score_gemma":0.0004374319,"domain_scores_codex":[0.999251,0.000008392776,0.00009580654,0.0003889957,0.00006581021,0.000190003],"domain_scores_gemma":[0.9992171,0.000009262823,0.0001305608,0.0005712561,0.00001779568,0.00005402247],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000008309051,0.00002265171,0.00001041202,0.00006663165,0.0002301373,5.404361e-7,0.00000110855,3.509367e-7,0.1814985,0.0001975357,0.8118527,0.00611112],"study_design_scores_gemma":[0.0001044255,0.00002394787,0.000001930111,0.00005669477,0.00008617684,0.000001310193,0.00001889808,0.0000056545,0.05882517,0.0001772371,0.9404653,0.0002332776],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.0003464537,0.002003779,0.002970673,0.00007692535,0.00006665147,0.0001750729,0.0001067005,0.00003706956,0.9942167],"genre_scores_gemma":[0.03252565,0.0006952347,0.001062457,0.00007123564,0.0006753657,0.00005729054,0.0001971391,0.0002158039,0.9644998],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.1286126,"threshold_uncertainty_score":0.6885462,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01104814475798013,"score_gpt":0.271007947708471,"score_spread":0.2599598029504909,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}