{"id":"W2765187137","doi":"10.1016/j.taap.2017.10.015","title":"Xanthatin triggers Chk1-mediated DNA damage response and destabilizes Cdc25C via lysosomal degradation in lung cancer cells","year":2017,"lang":"en","type":"article","venue":"Toxicology and Applied Pharmacology","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sinai Health System; Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"Canadian Institutes of Health Research; China Scholarship Council; China Postdoctoral Science Foundation; Natural Science Foundation of Jiangsu Province; National Natural Science Foundation of China; Jiangsu Province Postdoctoral Science Foundation","keywords":"Cell biology; DNA damage; Hyperphosphorylation; Cyclin-dependent kinase 1; CHEK1; Biology; Lysosome; Cell cycle; Mitotic catastrophe; Cell cycle checkpoint; Phosphorylation; Mitosis; Chemistry; Apoptosis; Cancer research; Biochemistry; DNA; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001520785,0.0002711332,0.0002414585,0.0002895015,0.0002873312,0.0003925704,0.0002313705,0.0003314533,0.001857748],"category_scores_gemma":[0.000107531,0.0001973097,0.0003645119,0.0002561742,0.0002316829,0.0002184869,0.0002637284,0.0006641368,0.0004234036],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005582668,"about_ca_system_score_gemma":0.0003745545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001719846,"about_ca_topic_score_gemma":0.002182844,"domain_scores_codex":[0.9998249,0.00002473933,0.00001799706,0.00003564183,0.00003575444,0.00006094636],"domain_scores_gemma":[0.9999344,0.00001006929,0.00001727747,0.00001456322,0.000007854411,0.00001583011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003958479,0.0000516626,0.0004339092,0.00005147866,0.00001715894,0.0001463896,0.00001946357,0.0001048213,0.9974367,0.000133027,0.0001357101,0.00107392],"study_design_scores_gemma":[0.00001711166,0.00008568699,0.00515018,0.000003040137,0.00001220197,0.0001463592,0.00003605846,0.0004825928,0.9928242,0.00002647938,0.001212486,0.000003633376],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950902,0.001839497,0.0008547679,0.0001513894,0.00003889054,0.00001853333,0.0005348932,0.00008496485,0.001386739],"genre_scores_gemma":[0.9966898,0.0004900575,0.0002682442,0.00003422424,0.000004556061,0.00001898203,0.0004432113,0.00000825573,0.002042705],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001857748,"threshold_uncertainty_score":0.006214797,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01067029928325565,"score_gpt":0.2944893743607674,"score_spread":0.2838190750775118,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}