{"id":"W2765192347","doi":"10.1101/gad.304261.117","title":"Suppression of protein tyrosine phosphatase N23 predisposes to breast tumorigenesis via activation of FYN kinase","year":2017,"lang":"en","type":"article","venue":"Genes & Development","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Cold Spring Harbor Laboratory; McGill University; National Cancer Institute; National Institutes of Health; Harvard University; Don Monti Memorial Research Foundation","keywords":"FYN; Cancer research; Biology; Breast cancer; Carcinogenesis; Protein tyrosine phosphatase; Tyrosine kinase; Proto-oncogene tyrosine-protein kinase Src; Cancer; Phosphorylation; Signal transduction; Cell biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000203509,0.0002341407,0.0002547166,0.00006368325,0.0002008793,0.00002619869,0.0005121009,0.000101545,0.00003584038],"category_scores_gemma":[0.0001402414,0.000217776,0.00006133679,0.00007280646,0.00009030435,0.00001910348,0.0005107459,0.00003758478,0.000008286206],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003020537,"about_ca_system_score_gemma":0.0002374593,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001628813,"about_ca_topic_score_gemma":0.00002475462,"domain_scores_codex":[0.9985529,0.00003295231,0.0004357937,0.0004195156,0.0002886478,0.0002701894],"domain_scores_gemma":[0.9983553,0.000006476313,0.0004079935,0.0008536087,0.0002481742,0.0001284018],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004859765,0.0001640305,0.00394827,0.0001274508,0.00004806753,0.000002624274,0.00004578814,0.0000332877,0.9143453,0.00007287668,0.0004669599,0.08025935],"study_design_scores_gemma":[0.0004851366,0.0001491106,0.07204655,0.0001929129,0.00001378077,0.000005303588,0.00001282216,0.000004650183,0.919385,0.00002602432,0.007449675,0.000229072],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907374,0.003748333,0.003939718,0.0001659462,0.0001496041,0.0009025115,0.0003107136,0.0000131859,0.00003262314],"genre_scores_gemma":[0.9839486,0.00007502934,0.01492329,0.00003610664,0.00008775733,0.0001985777,0.000548975,0.00002981244,0.0001518884],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08003028,"threshold_uncertainty_score":0.8880648,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01000217966747019,"score_gpt":0.2499410818398075,"score_spread":0.2399389021723373,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}