{"id":"W2765195981","doi":"10.1371/journal.pone.0186740","title":"Antioxidants and NOX1/NOX4 inhibition blocks TGFβ1-induced CCN2 and α-SMA expression in dermal and gingival fibroblasts","year":2017,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Connective Tissue Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"NOX1; NOX4; Myofibroblast; Molecular biology; NADPH oxidase; Chemistry; Western blot; Nicotinamide adenine dinucleotide phosphate; Type I collagen; Biology; Cancer research; Reactive oxygen species; Fibrosis; Pathology; Endocrinology; Biochemistry; Medicine; Oxidase test; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001386459,0.0001262879,0.0001569745,0.00006462859,0.0001839689,0.00009173804,0.00007647825,0.000131311,0.00001026255],"category_scores_gemma":[0.0002849535,0.0001287442,0.00001167002,0.00002255763,0.0001155733,0.00001978307,0.0003918274,0.0001290015,0.000001602316],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000884087,"about_ca_system_score_gemma":0.00001992507,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004576794,"about_ca_topic_score_gemma":0.0001050609,"domain_scores_codex":[0.9990692,0.00005101536,0.0001166208,0.0003812341,0.0001504894,0.0002314554],"domain_scores_gemma":[0.9994937,0.00002164174,0.00006022533,0.0002642504,0.00005272607,0.0001074736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008790536,0.00011587,0.1047319,0.00006692931,0.00002020972,0.00001318527,0.00006936723,5.789347e-8,0.8935162,0.000003050331,0.00001493956,0.001360314],"study_design_scores_gemma":[0.0008221131,0.0001795195,0.3138559,0.0001591008,0.00000736689,0.000008631418,0.00001869098,0.00005670614,0.6847281,0.00003898195,0.00001557637,0.0001092857],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989064,0.000396485,0.00001253137,0.0002346333,0.00001133625,0.0002383346,0.00001222236,0.00000740842,0.0001805955],"genre_scores_gemma":[0.9993111,0.0001922869,0.0002571901,0.00001891386,0.00008197453,0.00001551508,0.00001235227,0.00001600195,0.00009468039],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.209124,"threshold_uncertainty_score":0.5250037,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04674453764489795,"score_gpt":0.2780185553272387,"score_spread":0.2312740176823407,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}