{"id":"W2765199703","doi":"10.1016/j.ccell.2017.09.014","title":"H3.3K27M Cooperates with Trp53 Loss and PDGFRA Gain in Mouse Embryonic Neural Progenitor Cells to Induce Invasive High-Grade Gliomas","year":2017,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":270,"is_retracted":false,"has_abstract":false,"ca_institutions":"Jewish General Hospital; McGill University","funders":"H2020 European Research Council; National Cancer Institute; Canadian Institutes of Health Research; Biomedical Research Council; Medical Research Council; Fonds de Recherche du Québec - Santé; Brain Tumour Charity","keywords":"PDGFRA; Biology; Cancer research; ATRX; OLIG2; Glioma; Somatic cell; Embryonic stem cell; Gene knockdown; Mutation; Stromal cell; Genetics; Cell culture; Gene; Central nervous system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002611537,0.000434743,0.0003346242,0.0004629761,0.0003011726,0.0003723825,0.0004289538,0.0004354466,0.002107957],"category_scores_gemma":[0.0001400037,0.0002844455,0.0004843966,0.0002663671,0.0004534763,0.0002276351,0.0004228846,0.001064916,0.0008568525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004545973,"about_ca_system_score_gemma":0.0004665137,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002406081,"about_ca_topic_score_gemma":0.003332009,"domain_scores_codex":[0.9996815,0.00004685738,0.00003682297,0.00004432887,0.00009331331,0.00009717523],"domain_scores_gemma":[0.9998308,0.00002363811,0.00005107527,0.00003232025,0.000009842316,0.00005211975],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001660239,0.0000662133,0.0001825666,0.00001508756,0.00001058898,0.0001048498,0.00001260863,0.0001198488,0.9983982,0.0001558559,0.00008582918,0.0006822239],"study_design_scores_gemma":[0.00005986385,0.0001942088,0.003647487,0.000003860568,0.00002428518,0.0003788849,0.00004770437,0.001876342,0.9917891,0.00007308336,0.001897831,0.000007434899],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994466,0.0005621747,0.002178734,0.0002290776,0.00006120676,0.00004292648,0.0006152187,0.0001449736,0.001699821],"genre_scores_gemma":[0.9967676,0.0002007764,0.0005923225,0.00005291621,0.000006577128,0.00002909189,0.0003838431,0.00005260215,0.001914224],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002406081,"threshold_uncertainty_score":0.007051766,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0193500331689298,"score_gpt":0.2721234354262455,"score_spread":0.2527734022573157,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}