{"id":"W2765199703","doi":"10.1016/j.ccell.2017.09.014","title":"H3.3K27M Cooperates with Trp53 Loss and PDGFRA Gain in Mouse Embryonic Neural Progenitor Cells to Induce Invasive High-Grade Gliomas","year":2017,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":270,"is_retracted":false,"has_abstract":false,"ca_institutions":"Jewish General Hospital; McGill University","funders":"H2020 European Research Council; National Cancer Institute; Canadian Institutes of Health Research; Biomedical Research Council; Medical Research Council; Fonds de Recherche du Québec - Santé; Brain Tumour Charity","keywords":"PDGFRA; Biology; Cancer research; ATRX; OLIG2; Glioma; Somatic cell; Embryonic stem cell; Gene knockdown; Mutation; Stromal cell; Genetics; Cell culture; Gene; Central nervous system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006184083,0.0002739583,0.0004045236,0.00009366719,0.000158704,0.0001190768,0.0001600412,0.00009491575,0.00006488646],"category_scores_gemma":[0.00002354219,0.0002013566,0.00004026236,0.0001259341,0.0001165668,0.0001525262,0.00008478676,0.0001545734,0.00003114794],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002240036,"about_ca_system_score_gemma":0.0002202058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003139766,"about_ca_topic_score_gemma":0.004144105,"domain_scores_codex":[0.9987119,0.00003317196,0.0001821978,0.0004790081,0.0001934632,0.0004002675],"domain_scores_gemma":[0.9988967,0.00005168513,0.0001123234,0.0005243585,0.00009651521,0.0003183702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000890327,0.001516363,0.3696963,0.0004166129,0.0002252634,0.003359445,0.002037479,0.0005326469,0.6149919,0.0000543356,0.003097726,0.00318162],"study_design_scores_gemma":[0.005742311,0.000795771,0.04687986,0.0001977322,0.000115849,0.00003166873,0.000233263,0.00006667709,0.9449006,0.000004866409,0.0007644982,0.0002669191],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936408,0.00247424,7.87236e-7,0.002317377,0.0001979716,0.001084992,0.00005279264,0.00002754497,0.0002034353],"genre_scores_gemma":[0.9973139,0.0005727251,0.0001892045,0.0004777004,0.0001817599,0.0004426606,0.00001271108,0.00004708577,0.000762207],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3299087,"threshold_uncertainty_score":0.8211082,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0193500331689298,"score_gpt":0.2721234354262455,"score_spread":0.2527734022573157,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}