{"id":"W2765241801","doi":"10.1182/bloodadvances.2017007021","title":"Mature murine megakaryocytes present antigen-MHC class I molecules to T cells and transfer them to platelets","year":2017,"lang":"en","type":"article","venue":"Blood Advances","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":130,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Canadian Blood Services; University of Toronto; Centre hospitalier universitaire de Québec; St. Michael's Hospital","funders":"Health Canada; Hospital for Sick Children; China Scholarship Council; University of Toronto; Canadian Blood Services; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Institutes of Health; National Science Foundation","keywords":"Antigen; Antigen processing; CD8; Cell biology; MHC class I; Major histocompatibility complex; Platelet; MHC restriction; MHC class II; In vitro; Biology; Chemistry; Immunology; Molecular biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003958405,0.0002299981,0.000380667,0.00005449724,0.0002218119,0.00007782629,0.0001616579,0.00007159319,0.00004506119],"category_scores_gemma":[0.00002332418,0.0001696904,0.00006035153,0.00005181618,0.00005427925,0.0001730737,0.00006740615,0.00009992986,0.00006014883],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007942292,"about_ca_system_score_gemma":0.00002053701,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004456559,"about_ca_topic_score_gemma":0.00005804243,"domain_scores_codex":[0.9989032,0.00001102899,0.0001570997,0.0003920364,0.0002138528,0.0003227982],"domain_scores_gemma":[0.9992017,0.00002895184,0.00003241415,0.0004195439,0.00004070408,0.0002767341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004828065,0.006523692,0.1443607,0.001475385,0.003124838,0.01823386,0.005315908,0.0003970095,0.5530292,0.001846962,0.008098028,0.2527663],"study_design_scores_gemma":[0.005614153,0.000995049,0.06414433,0.000358974,0.0002809056,0.000362895,0.0001863247,0.00003133401,0.7231217,0.0005304487,0.2038832,0.0004906896],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869202,0.003582356,0.00004970584,0.003214689,0.0001241399,0.0006423617,0.00006610621,0.00004921647,0.005351271],"genre_scores_gemma":[0.9935729,0.002238388,0.002208177,0.0005635325,0.00009921312,0.0000406581,0.00001290674,0.00002833751,0.001235908],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2522756,"threshold_uncertainty_score":0.6919774,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0133673952817504,"score_gpt":0.2685148947305223,"score_spread":0.2551474994487719,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}