{"id":"W2765241801","doi":"10.1182/bloodadvances.2017007021","title":"Mature murine megakaryocytes present antigen-MHC class I molecules to T cells and transfer them to platelets","year":2017,"lang":"en","type":"article","venue":"Blood Advances","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":130,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Canadian Blood Services; University of Toronto; Centre hospitalier universitaire de Québec; St. Michael's Hospital","funders":"Health Canada; Hospital for Sick Children; China Scholarship Council; University of Toronto; Canadian Blood Services; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Institutes of Health; National Science Foundation","keywords":"Antigen; Antigen processing; CD8; Cell biology; MHC class I; Major histocompatibility complex; Platelet; MHC restriction; MHC class II; In vitro; Biology; Chemistry; Immunology; Molecular biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001099499,0.0003234942,0.0001180227,0.0001947056,0.0001037872,0.0002237713,0.0001387657,0.0002911787,0.00574633],"category_scores_gemma":[0.00009015728,0.0001150426,0.0001561187,0.0000898825,0.0001297497,0.0001917768,0.0001652678,0.0007133091,0.001521614],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000141644,"about_ca_system_score_gemma":0.0001030918,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001182403,"about_ca_topic_score_gemma":0.0001603193,"domain_scores_codex":[0.999945,0.00001260175,0.000005395293,0.000009719673,0.00001257745,0.0000146203],"domain_scores_gemma":[0.9999452,0.00001288702,0.00001069535,0.000006090502,0.000006452729,0.0000186491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00038045,0.00006143952,0.0002260259,0.00006582007,0.000007310392,0.00009531999,0.00001975501,0.000067716,0.9903464,0.001082226,0.0004739043,0.007173654],"study_design_scores_gemma":[0.0001251877,0.001287031,0.002627199,0.00002593112,0.00002548232,0.0004076242,0.00002005648,0.0005966962,0.9757201,0.0003850493,0.01877512,0.000004506076],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9497015,0.01197165,0.01656448,0.0009209606,0.0004026164,0.0002204925,0.001496369,0.000383258,0.0183387],"genre_scores_gemma":[0.9566099,0.005343869,0.01251237,0.0001432247,0.0001141215,0.0001324773,0.001442991,0.00004140657,0.02365959],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00574633,"threshold_uncertainty_score":0.01922339,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0133673952817504,"score_gpt":0.2685148947305223,"score_spread":0.2551474994487719,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}