{"id":"W2765257263","doi":"10.1021/acs.jmedchem.7b01198","title":"Amphiphilic Modulation of Glycosylated Antitumor Ether Lipids Results in a Potent Triamino Scaffold against Epithelial Cancer Cell Lines and BT474 Cancer Stem Cells","year":2017,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Cancer Society","keywords":"Cancer stem cell; Chemistry; Cancer; Cancer research; Cancer cell; Cytotoxicity; Salinomycin; Cisplatin; Apoptosis; Cell culture; Stem cell; Pharmacology; Biochemistry; Cell biology; Biology; Chemotherapy; In vitro; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008460385,0.0002386389,0.0001126334,0.0001285586,0.00006560169,0.0001584258,0.00009582834,0.0001670762,0.000613745],"category_scores_gemma":[0.00006415213,0.00006810143,0.0001188508,0.00008961599,0.0001159992,0.000153542,0.0001490562,0.0002916105,0.0001705588],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001300817,"about_ca_system_score_gemma":0.00009237391,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001884511,"about_ca_topic_score_gemma":0.0003259855,"domain_scores_codex":[0.9999528,0.000007849403,0.00000445053,0.000007248152,0.00001340291,0.00001431431],"domain_scores_gemma":[0.9999441,0.000008951654,0.00002223182,0.000005271744,0.000006386766,0.00001297915],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004350523,0.000008180202,0.00002610853,0.000008157213,0.000001309345,0.00001328557,0.00000460806,0.00005102811,0.9990764,0.00006061414,0.000009574,0.0006973166],"study_design_scores_gemma":[0.000004682025,0.0001061785,0.0002471196,9.447037e-7,0.000003296733,0.00002681635,0.000003825762,0.0002273196,0.9988621,0.000007952674,0.0005087855,0.000001011575],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997016,0.000365103,0.001355362,0.00004479893,0.000008146781,0.0000162833,0.00009122078,0.0000397944,0.00106325],"genre_scores_gemma":[0.9970828,0.0003964005,0.001303579,0.00002897025,0.000002910232,0.00001498054,0.0001197695,0.00001293089,0.001037637],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000613745,"threshold_uncertainty_score":0.002053201,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01884160333099768,"score_gpt":0.2796127763146656,"score_spread":0.2607711729836679,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}