{"id":"W2765257263","doi":"10.1021/acs.jmedchem.7b01198","title":"Amphiphilic Modulation of Glycosylated Antitumor Ether Lipids Results in a Potent Triamino Scaffold against Epithelial Cancer Cell Lines and BT474 Cancer Stem Cells","year":2017,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Cancer Society","keywords":"Cancer stem cell; Chemistry; Cancer; Cancer research; Cancer cell; Cytotoxicity; Salinomycin; Cisplatin; Apoptosis; Cell culture; Stem cell; Pharmacology; Biochemistry; Cell biology; Biology; Chemotherapy; In vitro; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003998842,0.0001650313,0.0003351364,0.00003404075,0.00005312341,0.00002026339,0.0002855171,0.000196316,0.00001915663],"category_scores_gemma":[0.00005870199,0.0001322622,0.0001006918,0.0000337517,0.0001412243,0.00001342554,0.00006726031,0.0001755284,3.143146e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004402165,"about_ca_system_score_gemma":0.0002022143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003165458,"about_ca_topic_score_gemma":0.0001004232,"domain_scores_codex":[0.9987203,0.00003100824,0.0006098051,0.000213975,0.0002494097,0.000175512],"domain_scores_gemma":[0.9984354,0.00001445059,0.0008960232,0.0002733595,0.0002727657,0.0001079639],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001303756,0.00007353576,0.002875996,0.0001281718,0.00005781184,0.00002494692,0.0001057142,0.0004024996,0.9868947,1.297062e-7,0.0004201971,0.007712581],"study_design_scores_gemma":[0.003039363,0.000252839,0.007457235,0.000543031,0.00005196752,0.00002251741,0.0001648452,0.0004219239,0.9873073,0.000006024231,0.0005963023,0.0001366232],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942543,0.004549163,0.00001453624,0.0004290088,0.0003418639,0.00007367459,0.00006183474,0.000001521447,0.0002741232],"genre_scores_gemma":[0.9915714,0.006684697,0.00004030452,0.00006486582,0.001036017,0.000003354226,0.000006674264,0.00001354194,0.0005792064],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007575958,"threshold_uncertainty_score":0.5393496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01884160333099768,"score_gpt":0.2796127763146656,"score_spread":0.2607711729836679,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}