{"id":"W2765263172","doi":"10.3390/antib6040016","title":"Antibodies and Derivatives Targeting DR4 and DR5 for Cancer Therapy","year":2017,"lang":"en","type":"review","venue":"Antibodies","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Regional Development Fund; Ligue Contre le Cancer; Fondation ARC pour la Recherche sur le Cancer; Agence Nationale de la Recherche; Institute of Cancer Research; Institut National Du Cancer; Association pour la Recherche sur le Cancer","keywords":"Receptor; Cancer therapy; Cancer; Agonist; Tumor necrosis factor alpha; Cytokine; Antibody; Cancer cell; Biology; Cancer research; Computational biology; Immunology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001436778,0.0003041181,0.0006590973,0.00004650864,0.0003764073,0.00009399047,0.0001075727,0.0002562201,0.000003448828],"category_scores_gemma":[0.0000484111,0.0002190688,0.0001544022,0.00001530011,0.0001753045,0.000006777726,0.0001228111,0.00006245048,3.584304e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004177545,"about_ca_system_score_gemma":0.00005336651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000210699,"about_ca_topic_score_gemma":0.00001936834,"domain_scores_codex":[0.9990664,0.00003453196,0.0002202653,0.0004227324,0.00005455742,0.0002015897],"domain_scores_gemma":[0.9993972,0.00002916904,0.0002694364,0.0002085532,0.00005776972,0.00003790317],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001009678,0.00000883718,0.0001146433,0.002927562,0.000233658,7.439692e-7,0.00006744445,1.199754e-7,0.003253514,0.0001553447,0.0005656643,0.9926624],"study_design_scores_gemma":[0.0001817325,0.00008524257,0.0001306059,0.001200216,0.000120405,0.00000651624,0.00003019745,0.000005276768,0.001199989,0.0001345265,0.9966057,0.0002995707],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001343296,0.9975387,0.0001655544,0.00003697348,0.000195472,0.0005172463,0.00007801758,0.000009261169,0.0001154119],"genre_scores_gemma":[0.0004320443,0.9965822,0.0008384985,0.00002356586,0.0004265581,0.00006862525,0.0003069006,0.0000415045,0.001280091],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.99604,"threshold_uncertainty_score":0.8933365,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07907894619068304,"score_gpt":0.3912741543676535,"score_spread":0.3121952081769704,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}