{"id":"W2765286077","doi":"10.1371/journal.pone.0182472","title":"Genetically defined elevated homocysteine levels do not result in widespread changes of DNA methylation in leukocytes","year":2017,"lang":"en","type":"review","venue":"PLoS ONE","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa; Public Health Ontario; University of Toronto","funders":"Medical Research Council; Centre for Cognitive Ageing and Cognitive Epidemiology; Directorate for Biological Sciences; Nederlandse Federatie van Universitair Medische Centra; Biotechnology and Biological Sciences Research Council; ZonMw; Canadian Institutes of Health Research; Royal Society; University of Queensland; University of Edinburgh; European Commission; Wellcome Trust; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Agence Nationale de la Recherche; Scottish Government; Age UK; National Heart, Lung, and Blood Institute; Heart and Stroke Foundation of Canada","keywords":"Methylenetetrahydrofolate reductase; DNA methylation; CpG site; Methylation; Homocysteine; Genetics; Biology; Single-nucleotide polymorphism; Genome-wide association study; Gene; Molecular biology; Genotype; Gene expression; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001657875,0.0003247537,0.0007439287,0.0006189142,0.0002736984,0.0006403359,0.0004258742,0.0006381475,0.001835751],"category_scores_gemma":[0.00510992,0.0002362076,0.001162227,0.001007618,0.000494665,0.0002394365,0.000404368,0.000436641,0.0001479569],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002261483,"about_ca_system_score_gemma":0.0002871734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001882734,"about_ca_topic_score_gemma":0.001920671,"domain_scores_codex":[0.9979735,0.0007315505,0.0001858084,0.000741838,0.0002452516,0.0001220552],"domain_scores_gemma":[0.9963052,0.001601033,0.001165191,0.0006659054,0.0001407338,0.0001218891],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004732948,0.00004789965,0.9233174,0.000689266,0.01310552,0.0006686941,0.0002409193,0.001025518,0.03767784,0.0006859734,0.0004048242,0.01740315],"study_design_scores_gemma":[0.0001491952,0.0005908224,0.9772932,0.00009279149,0.00822869,0.001595779,0.0001217816,0.001181543,0.007026582,0.001768961,0.001931905,0.00001872627],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867045,0.006836819,0.004006408,0.0002028389,0.00003480575,0.00002093938,0.001250402,0.00004645042,0.000896814],"genre_scores_gemma":[0.998817,0.0003077928,0.0004649235,0.00005773865,0.00001057528,0.000009425917,0.0002479282,0.000009282331,0.00007534958],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001882734,"threshold_uncertainty_score":0.008767784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3536590425626971,"score_gpt":0.4023914654791143,"score_spread":0.04873242291641716,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}