{"id":"W2765304775","doi":"10.1158/1078-0432.ccr-17-1621","title":"Homologous Recombination DNA Repair Pathway Disruption and Retinoblastoma Protein Loss Are Associated with Exceptional Survival in High-Grade Serous Ovarian Cancer","year":2017,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"Foothills Medical Centre; BC Cancer Agency","funders":"Medical Research and Materiel Command; National Health and Medical Research Council; Canadian Institutes of Health Research; Cancer Institute NSW; Cancer Australia; National Breast Cancer Foundation","keywords":"Homologous recombination; Serous fluid; Ovarian cancer; Retinoblastoma; Biology; DNA repair; Homologous chromosome; Serous ovarian cancer; Cancer; Cancer research; Genetics; DNA; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002288418,0.00008787812,0.0001545846,0.0004425014,0.0002295481,0.0002202314,0.0001275228,0.0001934858,0.0008985132],"category_scores_gemma":[0.0009915597,0.0000819444,0.0001159295,0.0003832028,0.000286874,0.0001171565,0.0002352513,0.0001901613,0.00007462814],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001351754,"about_ca_system_score_gemma":0.0001363115,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004383541,"about_ca_topic_score_gemma":0.00070542,"domain_scores_codex":[0.9998763,0.00003008684,0.0000162345,0.00002599884,0.00002288563,0.00002850288],"domain_scores_gemma":[0.9990559,0.0002309704,0.0004502176,0.00006700477,0.00004769313,0.0001483177],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001929931,0.00001103454,0.9947349,0.000008668748,0.00001461382,0.0002848317,0.00004192571,0.0000547277,0.00329723,0.00001276096,0.0000250687,0.00132138],"study_design_scores_gemma":[0.000004000654,0.0001045904,0.9964832,0.000001786727,0.00001105938,0.002179396,0.00009498284,0.000166178,0.0007987857,0.00003299225,0.000121354,0.00000162621],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999772,0.00007613585,0.00005203528,0.000005218489,4.84206e-7,0.000001542591,0.00003488992,0.000002076451,0.00005565449],"genre_scores_gemma":[0.9998617,0.00001804314,0.00002832978,0.000003073696,9.117153e-7,0.000001136559,0.00006256305,5.649028e-7,0.00002363722],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008985132,"threshold_uncertainty_score":0.003005803,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1761782669778747,"score_gpt":0.4742512406429381,"score_spread":0.2980729736650635,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}