{"id":"W2765322584","doi":"10.1101/cshperspect.a028886","title":"Will Systems Biology Deliver Its Promise and Contribute to the Development of New or Improved Vaccines?","year":2017,"lang":"en","type":"review","venue":"Cold Spring Harbor Perspectives in Biology","topic":"Evolution and Genetic Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute","keywords":"Biology; Malaria; Systems biology; Tuberculosis; Infectious disease (medical specialty); Disease; Immunology; Engineering ethics; Computational biology; Medicine; Engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004107034,0.001574745,0.001831625,0.002103284,0.0008645094,0.00365216,0.001779117,0.004259515,0.007638869],"category_scores_gemma":[0.00283727,0.0004545145,0.0009416761,0.001751706,0.004167469,0.007833146,0.001912999,0.007389134,0.006046751],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002733092,"about_ca_system_score_gemma":0.003995395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001516844,"about_ca_topic_score_gemma":0.001879998,"domain_scores_codex":[0.999222,0.0002240215,0.0000514528,0.0001096705,0.0002724754,0.0001203957],"domain_scores_gemma":[0.997333,0.001542127,0.0001125585,0.0001511771,0.0005479723,0.0003130542],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008753415,0.0001006419,0.0002637625,0.009294775,0.0001330669,0.0002262699,0.0002997614,0.000953011,0.00319209,0.1204432,0.1227206,0.7422852],"study_design_scores_gemma":[0.000007666044,0.00004554705,0.0001274212,0.001440383,0.00002193182,0.0002359319,0.00009272194,0.0001236848,0.0003205313,0.02197709,0.9755853,0.00002174675],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009180761,0.9851701,0.00108747,0.008293139,0.002379582,0.000005231876,0.00002216454,0.00003906299,0.002911419],"genre_scores_gemma":[0.001184859,0.9915335,0.00103963,0.00264961,0.001652198,0.00001233798,0.00002940713,0.00001464297,0.001883892],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.007638869,"threshold_uncertainty_score":0.0255546,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04519237819105915,"score_gpt":0.3545219982072452,"score_spread":0.309329620016186,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}