{"id":"W2765332035","doi":"10.1073/pnas.1711310114","title":"CRISPR/Cas9 knockouts reveal genetic interaction between strain-transcendent erythrocyte determinants of <i>Plasmodium falciparum</i> invasion","year":2017,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Government of Canada; National Institutes of Health; National Heart, Lung, and Blood Institute; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Wellcome Trust","keywords":"Biology; Gene knockout; CRISPR; CD44; Plasmodium falciparum; Gene; Haematopoiesis; Genetic screen; Genome editing; RNA interference; Genetics; Cell biology; Phenotype; Stem cell; Immunology; Cell; Malaria; RNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005900448,0.0001022924,0.0001576557,0.00007553891,0.000257578,0.00003020056,0.000852321,0.0001256662,0.000005265222],"category_scores_gemma":[0.0003932611,0.00007630009,0.0001010439,0.0000916654,0.0006213817,0.00005854206,0.0001830384,0.0001012693,6.72504e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001410071,"about_ca_system_score_gemma":0.00004535502,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001157249,"about_ca_topic_score_gemma":6.434001e-7,"domain_scores_codex":[0.9986032,0.00000922035,0.0003877686,0.0002532526,0.0006135278,0.0001330911],"domain_scores_gemma":[0.9988479,0.00001738681,0.0008253779,0.00002760503,0.0002432308,0.00003848096],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002690792,0.00002615861,0.04517112,0.00005820316,0.00001174288,5.555219e-9,0.00003884155,0.00001065681,0.9524863,0.0001399421,0.0005175575,0.001512509],"study_design_scores_gemma":[0.0001953253,0.000105507,0.1504301,0.0001021283,0.00001235214,0.000005032357,0.00005254217,0.00005287549,0.8475969,0.0009956659,0.0003815583,0.00006997951],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997647,0.00006914514,0.000006350944,0.0006240371,0.00005003897,0.0001767107,0.00005246822,0.000002805732,0.00137142],"genre_scores_gemma":[0.9988337,0.00006514688,0.0007439454,0.00006792842,0.000136745,0.000006167547,7.465995e-7,0.000004769274,0.0001409123],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.105259,"threshold_uncertainty_score":0.3111427,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05596000464235557,"score_gpt":0.3387520031292817,"score_spread":0.2827919984869261,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}