{"id":"W2765364956","doi":"10.2337/db17-0728","title":"Deletion of the Akt/mTORC1 Repressor REDD1 Prevents Visual Dysfunction in a Rodent Model of Type 1 Diabetes","year":2017,"lang":"en","type":"article","venue":"Diabetes","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Eye Institute; Canadian Institutes of Health Research; American Diabetes Association","keywords":"Endocrinology; Neurodegeneration; Diabetes mellitus; Internal medicine; Retinal; Type 2 diabetes; Retina; Streptozotocin; Protein kinase B; Programmed cell death; Biology; mTORC1; Apoptosis; Medicine; Neuroscience; Ophthalmology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002800649,0.000976262,0.0004920855,0.001008275,0.000271638,0.0003543075,0.0005685252,0.0004457227,0.001497624],"category_scores_gemma":[0.0001522177,0.0004132472,0.0003133603,0.000318133,0.00046447,0.0003277258,0.0003181588,0.001120129,0.0003665024],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005105067,"about_ca_system_score_gemma":0.0004195675,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007214408,"about_ca_topic_score_gemma":0.001414893,"domain_scores_codex":[0.9997855,0.00003273563,0.00002619322,0.00006128794,0.00004676859,0.00004762243],"domain_scores_gemma":[0.9996868,0.00002489675,0.0001551095,0.00002591723,0.00001674443,0.00009039257],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000859523,0.0002634804,0.000424607,0.0001187288,0.00001853566,0.0001463178,0.00002009045,0.000190484,0.9942912,0.0002820804,0.0001347643,0.003250127],"study_design_scores_gemma":[0.0002535386,0.002436584,0.009579245,0.00004939807,0.00009132667,0.0006929857,0.00007676906,0.001947975,0.9800802,0.0002159488,0.004555123,0.00002091973],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920064,0.002471874,0.002700963,0.0002105835,0.00006067541,0.00005645492,0.0008091814,0.0002950926,0.00138894],"genre_scores_gemma":[0.9833813,0.003380263,0.006252387,0.0001555716,0.00002047974,0.0001570939,0.001135224,0.0001186931,0.005398939],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001497624,"threshold_uncertainty_score":0.005010068,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01120835059659387,"score_gpt":0.2506753111149471,"score_spread":0.2394669605183533,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}