{"id":"W2765383827","doi":"10.1186/s12981-017-0185-4","title":"HIV treatment simplification to elvitegravir/cobicistat/emtricitabine/tenofovir disproxil fumarate (E/C/F/TDF) plus darunavir: a pharmacokinetic study","year":2017,"lang":"en","type":"article","venue":"AIDS Research and Therapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; AIDS Vancouver; St. Paul's Hospital; University of British Columbia Hospital","funders":"National Institute on Drug Abuse; Gilead Sciences","keywords":"Darunavir; Cobicistat; Medicine; Elvitegravir; Ritonavir; Regimen; Raltegravir; Emtricitabine; Viral load; Internal medicine; Pharmacology; Pharmacokinetics; Tenofovir alafenamide; Renal function; Adverse effect; Maraviroc; Human immunodeficiency virus (HIV); Virology; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008104418,0.0003853033,0.0005467295,0.0004874087,0.001140849,0.0003629401,0.0003403636,0.00007533641,0.0001755628],"category_scores_gemma":[0.00008337836,0.0002621426,0.00009346494,0.0003604909,0.000223289,0.0001999225,0.0001336958,0.0002709881,0.0003665761],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004699547,"about_ca_system_score_gemma":0.000377993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003218201,"about_ca_topic_score_gemma":0.00003972146,"domain_scores_codex":[0.9969653,0.0002081751,0.0003704542,0.0007877079,0.0008583523,0.0008100023],"domain_scores_gemma":[0.9976739,0.0001740583,0.0000926438,0.001108735,0.0003147791,0.0006358746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.007596641,0.006845542,0.2987993,0.00004969581,0.001525686,0.0007239805,0.008834175,0.000002680783,0.02588223,0.0004396509,0.004469162,0.6448312],"study_design_scores_gemma":[0.06668348,0.03259264,0.6292791,0.0002176926,0.0003292301,0.00007824734,0.004521466,0.0004463406,0.02911845,0.001902711,0.233575,0.001255634],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856706,0.001250997,0.00005839493,0.005605272,0.00007151756,0.003951341,0.00004009717,0.00007286262,0.003278864],"genre_scores_gemma":[0.9352797,0.002896404,0.0003872424,0.0001052996,0.0001681082,0.0009718625,0.00008800747,0.00005472696,0.06004861],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6435756,"threshold_uncertainty_score":0.9999831,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.148074484666812,"score_gpt":0.4550284880517627,"score_spread":0.3069540033849507,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}