{"id":"W2765383827","doi":"10.1186/s12981-017-0185-4","title":"HIV treatment simplification to elvitegravir/cobicistat/emtricitabine/tenofovir disproxil fumarate (E/C/F/TDF) plus darunavir: a pharmacokinetic study","year":2017,"lang":"en","type":"article","venue":"AIDS Research and Therapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; AIDS Vancouver; St. Paul's Hospital; University of British Columbia Hospital","funders":"National Institute on Drug Abuse; Gilead Sciences","keywords":"Darunavir; Cobicistat; Medicine; Elvitegravir; Ritonavir; Regimen; Raltegravir; Emtricitabine; Viral load; Internal medicine; Pharmacology; Pharmacokinetics; Tenofovir alafenamide; Renal function; Adverse effect; Maraviroc; Human immunodeficiency virus (HIV); Virology; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00111727,0.0004411932,0.0007199864,0.000311252,0.0003652357,0.0004285629,0.0004681114,0.0004571682,0.001649072],"category_scores_gemma":[0.001785931,0.0003573997,0.0005982949,0.0002253237,0.0004348576,0.000460025,0.0002854124,0.001048543,0.0001678064],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006405896,"about_ca_system_score_gemma":0.0005634548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001000246,"about_ca_topic_score_gemma":0.001462756,"domain_scores_codex":[0.9993445,0.0003096045,0.00004439574,0.0001018547,0.0001180987,0.00008156239],"domain_scores_gemma":[0.9991323,0.000224841,0.0003042612,0.00008774856,0.00005744344,0.0001933721],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5252237,0.180366,0.03549986,0.0006387322,0.001706539,0.0003932864,0.001215644,0.005041099,0.07688257,0.0002318047,0.0008099368,0.1719908],"study_design_scores_gemma":[0.06788331,0.8529581,0.06465117,0.00003108866,0.0004846708,0.0003745794,0.0001179245,0.003605378,0.008114766,0.0001118484,0.001637208,0.00002993913],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993306,0.0001133811,0.00009935518,0.00001584786,0.000004111741,0.0002483454,0.00003036248,0.000004323891,0.0001535426],"genre_scores_gemma":[0.9984621,0.0001677905,0.0005740447,0.00007641978,0.00004367714,0.0002290715,0.0001337015,0.000003032659,0.0003101662],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001649072,"threshold_uncertainty_score":0.005908787,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.148074484666812,"score_gpt":0.4550284880517627,"score_spread":0.3069540033849507,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}