{"id":"W2765403479","doi":"10.1016/j.redox.2017.10.019","title":"Glutaredoxin-2 controls cardiac mitochondrial dynamics and energetics in mice, and protects against human cardiac pathologies","year":2017,"lang":"en","type":"article","venue":"Redox Biology","topic":"Redox biology and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Heart and Stroke Foundation of Canada; Canadian Institutes of Health Research; University of Ottawa","keywords":"Glutaredoxin; Mitochondrion; mitochondrial fusion; Biology; Glutathione; Internal medicine; Endocrinology; Fibrosis; Cardiac function curve; Myocyte; Cell biology; Cardiac fibrosis; Oxidative stress; Mitochondrial DNA; Medicine; Biochemistry; Thioredoxin; Heart failure; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002742799,0.0005540705,0.0003249466,0.0007204349,0.0002288717,0.0003735587,0.0002653325,0.0004639063,0.001520713],"category_scores_gemma":[0.0001453374,0.0002492594,0.0002758763,0.0002249352,0.0005735912,0.0003090403,0.0002666441,0.0007047793,0.0002576913],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003268518,"about_ca_system_score_gemma":0.0002425485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006356051,"about_ca_topic_score_gemma":0.001060999,"domain_scores_codex":[0.9998158,0.00003085362,0.00002217112,0.00006935487,0.00002937804,0.00003260781],"domain_scores_gemma":[0.999822,0.0000119847,0.00006383859,0.0000257717,0.00001188969,0.00006454374],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008717916,0.00009719627,0.0005588491,0.00003285842,0.00001912558,0.00006759969,0.00002100261,0.00007641662,0.9967027,0.0001759977,0.00007087009,0.001305544],"study_design_scores_gemma":[0.0002070772,0.001380428,0.01696527,0.00002428316,0.0001253618,0.0007732785,0.00009987647,0.001598462,0.9753485,0.0004574911,0.003002663,0.00001724866],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929395,0.001426077,0.003971932,0.0002425956,0.00005737617,0.00002344355,0.0005552603,0.0002094544,0.0005743593],"genre_scores_gemma":[0.9943128,0.0006772222,0.001608022,0.00007917287,0.000014055,0.00003200454,0.0004917979,0.00005578934,0.002729165],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001520713,"threshold_uncertainty_score":0.005087316,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007297179009158563,"score_gpt":0.2658212388148159,"score_spread":0.2585240598056573,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}