{"id":"W2765413024","doi":"10.7150/thno.21848","title":"Past, Present, and Future: Development of Theranostic Agents Targeting Carbonic Anhydrase IX","year":2017,"lang":"en","type":"review","venue":"Theranostics","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"Canadian Institutes of Health Research; Leading Edge Endowment Fund","keywords":"Monoclonal antibody; Cancer research; Medicine; Antibody; Cancer; Small molecule; Metastasis; Radioimmunotherapy; Pharmacology; Chemistry; Immunology; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002186486,0.0003491485,0.0006304274,0.00005982184,0.0001153459,0.00003368759,0.0002210815,0.000371368,0.00001869877],"category_scores_gemma":[0.00004710649,0.0002868302,0.0001681007,0.00004454643,0.00009802878,0.00000383242,0.0001334279,0.0001686954,0.000005008059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001994885,"about_ca_system_score_gemma":0.0002223488,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002835239,"about_ca_topic_score_gemma":0.000002035879,"domain_scores_codex":[0.998606,0.0001184463,0.000506793,0.000372277,0.0001632569,0.0002332087],"domain_scores_gemma":[0.9988565,0.00003217581,0.0004753234,0.0004653607,0.00008340205,0.000087262],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003612273,0.00009866287,0.00001745444,0.00374436,0.0004024374,0.000005768406,0.0001557785,0.000001597655,0.002066998,0.00002684197,0.007458834,0.9859852],"study_design_scores_gemma":[0.0002959559,0.0000845684,0.00001440531,0.001003515,0.0002198318,0.000009970001,0.00001664997,0.000004428353,0.001180713,0.000007503002,0.996868,0.000294521],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003953445,0.9977112,0.0002824702,0.00002730761,0.0005232644,0.0004365892,0.00003482141,0.00003002675,0.0005589418],"genre_scores_gemma":[0.0005439302,0.9954789,0.0004612032,0.00004220591,0.002422204,0.00002976574,0.0005261892,0.0001155203,0.0003800962],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9894091,"threshold_uncertainty_score":0.9999584,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05294396114866762,"score_gpt":0.3292002060172926,"score_spread":0.2762562448686249,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}