{"id":"W2765413024","doi":"10.7150/thno.21848","title":"Past, Present, and Future: Development of Theranostic Agents Targeting Carbonic Anhydrase IX","year":2017,"lang":"en","type":"review","venue":"Theranostics","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"Canadian Institutes of Health Research; Leading Edge Endowment Fund","keywords":"Monoclonal antibody; Cancer research; Medicine; Antibody; Cancer; Small molecule; Metastasis; Radioimmunotherapy; Pharmacology; Chemistry; Immunology; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005599307,0.0006866755,0.0009902603,0.001641291,0.0002727126,0.001037299,0.0007990519,0.001111286,0.003558003],"category_scores_gemma":[0.0006030656,0.0002728631,0.0004366989,0.001646418,0.0004153605,0.001715051,0.0007409878,0.001875619,0.002206748],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006297784,"about_ca_system_score_gemma":0.0009189305,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006936428,"about_ca_topic_score_gemma":0.001304205,"domain_scores_codex":[0.9998567,0.00002356134,0.00001631511,0.00002727393,0.00005438563,0.00002179754],"domain_scores_gemma":[0.9997757,0.00008800148,0.00003016268,0.00000808755,0.00006316122,0.00003491678],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007687655,0.00007468405,0.000123525,0.01245509,0.00005883514,0.0002293935,0.00008595597,0.0005369175,0.003188694,0.007797393,0.03983173,0.9355409],"study_design_scores_gemma":[0.00001191315,0.00006020234,0.0003144622,0.001677791,0.00003986946,0.0005454453,0.00003837017,0.0001178079,0.0004910043,0.002134277,0.9945561,0.00001285716],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002110016,0.996917,0.0002271158,0.0005772769,0.0003748449,0.000005565284,0.0000231407,0.00001403964,0.001649952],"genre_scores_gemma":[0.0009918682,0.9970918,0.000249483,0.0003526676,0.0002052002,0.000009855046,0.00002971551,0.000002908904,0.001066512],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003558003,"threshold_uncertainty_score":0.01190275,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05294396114866762,"score_gpt":0.3292002060172926,"score_spread":0.2762562448686249,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}