{"id":"W2765416776","doi":"10.1016/j.bmc.2017.10.020","title":"Influence of hydrocarbon-stapling on membrane interactions of synthetic antimicrobial peptides","year":2017,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; Canada Research Chairs; University of Toronto","funders":"Cystic Fibrosis Foundation","keywords":"Chemistry; Membrane; Circular dichroism; Peptide; Antimicrobial; Biophysics; Stereochemistry; Antimicrobial peptides; Biochemistry; Combinatorial chemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001484228,0.0002041744,0.0004379726,0.00006672568,0.0002430575,0.00001154391,0.0004838407,0.0001751309,0.0002796123],"category_scores_gemma":[0.000273136,0.0001813377,0.0001210829,0.00006402563,0.0009702968,0.0001025195,0.0001327663,0.0003465799,0.00003710873],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002493689,"about_ca_system_score_gemma":0.00008077321,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002684277,"about_ca_topic_score_gemma":0.000005790711,"domain_scores_codex":[0.9989865,0.000022735,0.0004013933,0.0002741748,0.00006093126,0.0002542993],"domain_scores_gemma":[0.9986142,0.0001316801,0.0005505914,0.0005862374,0.00008810531,0.00002921125],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000146881,0.0001329391,0.0008481566,0.0002312329,0.0001147667,0.00000508972,0.0001560285,0.00002227192,0.9975331,0.00002854413,0.0005869566,0.0001940491],"study_design_scores_gemma":[0.0005838679,0.00007163688,0.002825693,0.0008613169,0.00008318098,0.000101926,0.0002619525,0.000002794909,0.9946378,0.00001940628,0.0003958384,0.0001545506],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995917,0.0001354342,0.000009887133,0.0003327036,0.0002131924,0.00007802102,0.00004664172,0.00002638207,0.003240735],"genre_scores_gemma":[0.9987352,0.0001537771,0.00002652857,0.00005352507,0.00007956424,0.000002010274,0.00002029711,0.00001933752,0.0009097023],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002895247,"threshold_uncertainty_score":0.7394737,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01205625658000965,"score_gpt":0.2458548280552562,"score_spread":0.2337985714752465,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}