{"id":"W2765440580","doi":"10.1016/j.jalz.2017.06.2013","title":"[P4–147]: ISOPRENOIDS PATHWAY, TAU PHOSPHORYLATION AND ALZHEIMER's DISEASE","year":2017,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Plant biochemistry and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"","keywords":"Prenylation; Geranylgeranyl pyrophosphate; Mevalonate pathway; Farnesyl pyrophosphate; RHOA; Phosphorylation; Tau protein; Biology; Biochemistry; Enzyme; GTPase; Chemistry; Alzheimer's disease; Signal transduction; Cell biology; Internal medicine; Disease; ATP synthase; Medicine; Biosynthesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002319941,0.00108665,0.0005198246,0.0007666536,0.0005599505,0.0009611968,0.0005484108,0.001201262,0.02281014],"category_scores_gemma":[0.0002763407,0.0001460537,0.0003125806,0.001175971,0.0003402532,0.0004555204,0.0003851202,0.000849444,0.009707174],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005199002,"about_ca_system_score_gemma":0.0007994378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0034997,"about_ca_topic_score_gemma":0.002212704,"domain_scores_codex":[0.9998819,0.00002473276,0.000009415498,0.00003295876,0.00002893153,0.00002200388],"domain_scores_gemma":[0.9998488,0.00001209196,0.00003260628,0.000006631043,0.00006056182,0.00003923133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009163881,0.00131831,0.02926896,0.01222251,0.0006261194,0.00740374,0.0005167869,0.0009616188,0.206866,0.008839653,0.194786,0.5280264],"study_design_scores_gemma":[0.0005305233,0.003656403,0.3579303,0.002299502,0.0007335632,0.01711473,0.0009253664,0.001276839,0.03606752,0.01415475,0.565192,0.0001183629],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.1935695,0.5867499,0.005775495,0.01745385,0.01309349,0.0005090105,0.01304258,0.0008507554,0.1689554],"genre_scores_gemma":[0.5177896,0.2201511,0.00755958,0.005061957,0.007205907,0.0008393272,0.01326501,0.0001467586,0.2279807],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.02281014,"threshold_uncertainty_score":0.07630748,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0176125351286581,"score_gpt":0.2442785074810162,"score_spread":0.2266659723523581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}