{"id":"W2765452493","doi":"10.3390/vaccines5040038","title":"An Archaeosome-Adjuvanted Vaccine and Checkpoint Inhibitor Therapy Combination Significantly Enhances Protection from Murine Melanoma","year":2017,"lang":"en","type":"article","venue":"Vaccines","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"Government of Ontario; Ontario Institute for Cancer Research","keywords":"CD8; Ovalbumin; Cytotoxic T cell; Medicine; Melanoma; Vaccine therapy; Antigen; Cancer research; Immunotherapy; Immunology; Combination therapy; In vivo; Cancer vaccine; Immune system; Pharmacology; Biology; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001411006,0.0003612701,0.0004493215,0.0002999427,0.00008950062,0.0002479992,0.0002282199,0.0002608327,0.0005402296],"category_scores_gemma":[0.00009729328,0.0001391541,0.0002539905,0.0001569376,0.0001542427,0.0002123173,0.0002028713,0.0006290243,0.0001672911],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001344789,"about_ca_system_score_gemma":0.0003392295,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004401764,"about_ca_topic_score_gemma":0.00105778,"domain_scores_codex":[0.9998856,0.00002525817,0.00001106982,0.00001833036,0.00002644999,0.00003325041],"domain_scores_gemma":[0.9999332,0.000007485007,0.00001560548,0.00001070911,0.000006476659,0.00002651318],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004326449,0.001750317,0.0004754635,0.0001460902,0.00004689376,0.00007294439,0.00004750345,0.000754313,0.971291,0.0001560245,0.0002158607,0.02071715],"study_design_scores_gemma":[0.0006447573,0.03454125,0.005050996,0.00003241624,0.0001691239,0.0003323094,0.00004238557,0.002867805,0.9505503,0.00008793222,0.005660264,0.0000204802],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969785,0.001072559,0.0008226002,0.00005838829,0.00006077424,0.00007205243,0.0001102059,0.00006196061,0.0007630598],"genre_scores_gemma":[0.9956097,0.0009403391,0.001192858,0.0000363396,0.00001966096,0.00006165841,0.0002900373,0.000009892092,0.001839551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005402296,"threshold_uncertainty_score":0.001807213,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01727232486396238,"score_gpt":0.2573022605095601,"score_spread":0.2400299356455977,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}