{"id":"W2765458529","doi":"10.1007/978-1-4939-7374-3_1","title":"An Overview of Recent Therapeutics Advances for Duchenne Muscular Dystrophy","year":2017,"lang":"en","type":"review","venue":"Methods in molecular biology","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"","keywords":"Duchenne muscular dystrophy; Medicine; Dystrophin; Muscular dystrophy; Proinflammatory cytokine; Bioinformatics; Exon skipping; Sarcolemma; Dysferlin; Internal medicine; Inflammation; Exon; Biology; Genetics; Alternative splicing; Myocyte; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001284129,0.0005547013,0.001894328,0.0001726004,0.00008297519,0.00001218368,0.001057397,0.001175753,0.00002038556],"category_scores_gemma":[0.0004399873,0.0004720083,0.000756731,0.0001319873,0.0004146144,0.000005336401,0.0001909651,0.0002878592,0.000001265721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002155829,"about_ca_system_score_gemma":0.000264098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008610197,"about_ca_topic_score_gemma":0.00001149116,"domain_scores_codex":[0.9954696,0.002199434,0.000804396,0.0009739259,0.00006346525,0.0004891874],"domain_scores_gemma":[0.9972656,0.0001230584,0.0007652955,0.001618077,0.0001496649,0.00007829715],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007751035,0.000139166,0.000005417459,0.003174409,0.0003038313,0.000002223719,0.000006680205,0.000009217497,0.04846532,0.001307162,0.000005868459,0.9465032],"study_design_scores_gemma":[0.0004780782,0.0009055149,0.000002706972,0.0004173796,0.0003626248,0.000007121193,0.000007479171,0.000007151303,0.00529948,0.004561503,0.9874785,0.0004724549],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00002643858,0.8359324,0.1625489,0.00001502681,0.0003724582,0.0008684278,0.0001049502,0.000007892534,0.0001234588],"genre_scores_gemma":[0.000004632502,0.7965817,0.2019487,0.0001268552,0.0001033269,0.0003313937,0.0008255363,0.0000649852,0.0000129228],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9874727,"threshold_uncertainty_score":0.9997731,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2126574791241952,"score_gpt":0.5546306718479649,"score_spread":0.3419731927237696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}