{"id":"W2765533141","doi":"10.1101/206110","title":"Enhanced Astrocyte Responses are Driven by a Genetic Risk Allele Associated with Multiple Sclerosis","year":2017,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Multiple Sclerosis Society; Multiple Sclerosis Society of Canada; Li Ka Shing Foundation; Nancy Taylor Foundation for Chronic Diseases; National Institutes of Health; Yale University; National Multiple Sclerosis Society","keywords":"Multiple sclerosis; Astrocyte; Immune system; Biology; Immunology; Microglia; Allele; Central nervous system; Inflammation; Neuroscience; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001007213,0.000351388,0.0004416504,0.000339293,0.0004748341,0.0005830826,0.0003029899,0.0009181896,0.01625505],"category_scores_gemma":[0.003434524,0.0001590606,0.0002606162,0.0002419148,0.0002599618,0.000273356,0.0003664267,0.000651344,0.002599618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003874743,"about_ca_system_score_gemma":0.0004071368,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006075642,"about_ca_topic_score_gemma":0.001295378,"domain_scores_codex":[0.999584,0.00009875069,0.00005224725,0.00008781075,0.0001492683,0.00002797149],"domain_scores_gemma":[0.9981276,0.0007848878,0.0003666956,0.000115913,0.000446585,0.0001582745],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.002167494,0.0001638766,0.01707716,0.001993697,0.000234544,0.002060646,0.0004303302,0.000361458,0.1079538,0.002869723,0.8314487,0.03323844],"study_design_scores_gemma":[0.0007810402,0.001555898,0.1987277,0.001173773,0.0006449443,0.01322002,0.001056196,0.004306919,0.1909366,0.01468637,0.5726293,0.000281194],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4343068,0.009978534,0.01248342,0.2792332,0.1609105,0.0002989948,0.07564214,0.003727308,0.02341908],"genre_scores_gemma":[0.8182486,0.005531319,0.01039309,0.0332192,0.03564414,0.0002972274,0.02009879,0.001012907,0.07555478],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01625505,"threshold_uncertainty_score":0.05437857,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03868305468927471,"score_gpt":0.2592887948616819,"score_spread":0.2206057401724072,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}