{"id":"W2765624114","doi":"10.1523/jneurosci.1668-17.2017","title":"Abrogated Freud-1/Cc2d1a Repression of 5-HT1A Autoreceptors Induces Fluoxetine-Resistant Anxiety/Depression-Like Behavior","year":2017,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Ottawa Mental Health Centre; Ottawa Hospital; University of Ottawa","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Canadian Institutes of Health Research; Harvard University","keywords":"Autoreceptor; Serotonin; Antidepressant; Psychology; Dorsal raphe nucleus; Fluoxetine; Serotonergic; Anxiety; Endocrinology; Internal medicine; Neuroscience; Biology; Medicine; Psychiatry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000105771,0.0004594338,0.0003689384,0.0004024747,0.0001969436,0.0002666766,0.0003450732,0.0004148162,0.001847836],"category_scores_gemma":[0.0001063607,0.0001860903,0.0003073024,0.0001784118,0.000376688,0.0001309184,0.0002090246,0.0009078018,0.0003936386],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005134849,"about_ca_system_score_gemma":0.0002327092,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001834782,"about_ca_topic_score_gemma":0.003776933,"domain_scores_codex":[0.9998127,0.00001663571,0.00002170641,0.00005060651,0.00003954831,0.00005885503],"domain_scores_gemma":[0.9998541,0.0000203176,0.00005258394,0.00001344293,0.000008869453,0.0000507967],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001233579,0.00004067844,0.0001281432,0.00002276057,0.000005084114,0.00004664549,0.00001082359,0.00006388489,0.9988701,0.00009823827,0.00004140222,0.0005487647],"study_design_scores_gemma":[0.00006034682,0.0004448024,0.007149274,0.00001178243,0.00002993362,0.0003757345,0.00004917423,0.001759593,0.9872846,0.0000534184,0.002767089,0.00001415829],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958174,0.0008374365,0.001495086,0.00009736215,0.00004189163,0.00002523214,0.000888567,0.00008545697,0.0007115597],"genre_scores_gemma":[0.9940144,0.000531799,0.001298553,0.00007233228,0.000009140095,0.00006011788,0.001060045,0.00004153131,0.002912154],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001847836,"threshold_uncertainty_score":0.006181598,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05168143968565757,"score_gpt":0.3325173637266975,"score_spread":0.2808359240410399,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}