{"id":"W2765628679","doi":"10.1038/mi.2017.74","title":"NOX1 loss-of-function genetic variants in patients with inflammatory bowel disease","year":2017,"lang":"en","type":"article","venue":"Mucosal Immunology","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; NIHR Cambridge Biomedical Research Centre; Medical Research Council; National Institutes of Health; Boehringer Ingelheim Stiftung; Crohn's and Colitis UK; Deutsche Forschungsgemeinschaft; Science Foundation Ireland; NIHR BioResource; General Sir John Monash Foundation; Leona M. and Harry B. Helmsley Charitable Trust; Academy of Medical Sciences; Cancer Research UK; Alan Turing Institute; National Cancer Institute; British Heart Foundation; Crohn's and Colitis Foundation of America; Francis Crick Institute; Wellcome Trust; NHS Blood and Transplant; National Institute for Health and Care Research","keywords":"Inflammatory bowel disease; NOX1; Biology; Exome sequencing; Ulcerative colitis; Genetics; Cancer research; Phenotype; Disease; Pathology; Medicine; Gene; NADPH oxidase; Reactive oxygen species","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002228787,0.0005266445,0.0003937198,0.0007318807,0.0003873092,0.0003864137,0.0002922815,0.0006256197,0.001763471],"category_scores_gemma":[0.001151222,0.000167674,0.000247671,0.0006646376,0.0002778635,0.000197649,0.0002977761,0.0003247756,0.0002289197],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001705084,"about_ca_system_score_gemma":0.0001118971,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009633757,"about_ca_topic_score_gemma":0.0007251294,"domain_scores_codex":[0.9997481,0.00003808326,0.00003133468,0.0001022627,0.0000476306,0.00003260834],"domain_scores_gemma":[0.9996827,0.00008178585,0.0001250281,0.00002114886,0.00003065951,0.000058753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001077024,0.00008350472,0.952885,0.00006881553,0.0001291047,0.01509329,0.0003785255,0.000239981,0.0201511,0.0001998217,0.000437637,0.009256135],"study_design_scores_gemma":[0.00004279947,0.0002198503,0.9636497,0.00003246517,0.0001444986,0.03186857,0.0001678192,0.0004543184,0.00214068,0.0002112449,0.001053707,0.00001430521],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981115,0.0005479768,0.000267646,0.00006614684,0.00001053124,0.000009498279,0.0002472425,0.00001584988,0.000723692],"genre_scores_gemma":[0.9994065,0.0001350179,0.0001539364,0.00002886473,0.000009692422,0.000003344517,0.0001439533,0.000003590149,0.0001151832],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001763471,"threshold_uncertainty_score":0.00589937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007833085835511585,"score_gpt":0.2099870023680518,"score_spread":0.2021539165325402,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}