{"id":"W2765628679","doi":"10.1038/mi.2017.74","title":"NOX1 loss-of-function genetic variants in patients with inflammatory bowel disease","year":2017,"lang":"en","type":"article","venue":"Mucosal Immunology","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; NIHR Cambridge Biomedical Research Centre; Medical Research Council; National Institutes of Health; Boehringer Ingelheim Stiftung; Crohn's and Colitis UK; Deutsche Forschungsgemeinschaft; Science Foundation Ireland; NIHR BioResource; General Sir John Monash Foundation; Leona M. and Harry B. Helmsley Charitable Trust; Academy of Medical Sciences; Cancer Research UK; Alan Turing Institute; National Cancer Institute; British Heart Foundation; Crohn's and Colitis Foundation of America; Francis Crick Institute; Wellcome Trust; NHS Blood and Transplant; National Institute for Health and Care Research","keywords":"Inflammatory bowel disease; NOX1; Biology; Exome sequencing; Ulcerative colitis; Genetics; Cancer research; Phenotype; Disease; Pathology; Medicine; Gene; NADPH oxidase; Reactive oxygen species","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001194067,0.0002547416,0.0003451457,0.0002033189,0.000285253,0.00002034628,0.0005087265,0.0002438949,0.0003399923],"category_scores_gemma":[0.00009387761,0.0002137371,0.000062713,0.00005929107,0.0005865589,0.0002430493,0.0002320655,0.0003279753,0.0003849489],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000466766,"about_ca_system_score_gemma":0.0001079266,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006184038,"about_ca_topic_score_gemma":0.00004530357,"domain_scores_codex":[0.9985203,0.0001979026,0.0003732713,0.0004112419,0.00005249593,0.0004448597],"domain_scores_gemma":[0.9985486,0.00004476263,0.0003449532,0.0008900418,0.0001390403,0.00003254797],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003585096,0.0004755167,0.8777615,0.00003822771,0.000298772,0.00006506989,0.000107671,0.00000989696,0.1111934,0.003422685,0.00005947772,0.002982659],"study_design_scores_gemma":[0.004701828,0.0006274401,0.9790729,0.00006516381,0.00005732252,0.000004987348,0.00001904698,0.000001900043,0.01391652,0.000641108,0.0006552334,0.0002365782],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972844,0.0007378296,0.0002267956,0.0001216595,0.0009543874,0.0003706489,0.00003927824,0.00003668981,0.000228357],"genre_scores_gemma":[0.9992697,0.00006037017,0.00007663956,0.00008439188,0.00002362739,0.00004179258,0.0001035758,0.00003022855,0.0003097232],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1013113,"threshold_uncertainty_score":0.8715948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007833085835511585,"score_gpt":0.2099870023680518,"score_spread":0.2021539165325402,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}