{"id":"W2765633725","doi":"10.1016/j.antiviral.2017.10.018","title":"Immunogenicity and efficacy of replication-competent recombinant influenza virus carrying multimeric M2 extracellular domains in a chimeric hemagglutinin conjugate","year":2017,"lang":"en","type":"article","venue":"Antiviral Research","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Animal and Plant Quarantine Agency","keywords":"Virology; Immunogenicity; Hemagglutinin (influenza); Virus; Epitope; Biology; Recombinant DNA; Influenza A virus; Recombinant virus; Antigenic drift; Immune system; Antibody; Microbiology; Immunology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000681934,0.0004894746,0.000256533,0.0002349834,0.0001961064,0.0004148615,0.0003244668,0.000570794,0.0007368076],"category_scores_gemma":[0.0006125849,0.0001838033,0.0003530856,0.0001220404,0.000386362,0.0005468646,0.0001914005,0.0009143449,0.0002314007],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003865772,"about_ca_system_score_gemma":0.0002692616,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006151898,"about_ca_topic_score_gemma":0.0002308307,"domain_scores_codex":[0.9996765,0.0001029514,0.00002862187,0.00004563506,0.00006158675,0.00008469607],"domain_scores_gemma":[0.9996235,0.0001359455,0.00005984607,0.00005429843,0.00005907894,0.00006732089],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002973266,0.0006860744,0.0007234754,0.00004535431,0.00002692937,0.00007195293,0.00005446775,0.0004321464,0.9931144,0.000174216,0.00005097815,0.001646805],"study_design_scores_gemma":[0.0002893829,0.01093173,0.004694034,0.000008007427,0.00007826708,0.0003166324,0.00004363191,0.002396875,0.9804944,0.00008765095,0.000648661,0.00001068139],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989232,0.0002572671,0.000368742,0.00001957426,0.00001959357,0.00001360765,0.00004723215,0.000009121083,0.0003415605],"genre_scores_gemma":[0.9991423,0.00009427184,0.0001542686,0.00002054964,0.00001326406,0.000008690202,0.000194447,0.000004780411,0.0003674298],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007368076,"threshold_uncertainty_score":0.003606498,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1900535117901409,"score_gpt":0.4699063009794167,"score_spread":0.2798527891892758,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}