{"id":"W2765646098","doi":"10.1160/th17-06-0429","title":"Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Dabigatran Etexilate Oral Liquid Formulation in Infants with Venous Thromboembolism","year":2017,"lang":"en","type":"article","venue":"Thrombosis and Haemostasis","topic":"Blood Coagulation and Thrombosis Mechanisms","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University of Toronto; University of Alberta; Children's Hospital of Eastern Ontario; Hospital for Sick Children; University of Ottawa","funders":"","keywords":"Medicine; Dabigatran; Pharmacodynamics; Tolerability; Partial thromboplastin time; Pharmacokinetics; Dosing; Anesthesia; Direct thrombin inhibitor; Adverse effect; Thrombin time; Population; Nomogram; Anticoagulant; Internal medicine; Coagulation; Warfarin; Atrial fibrillation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006007302,0.00028867,0.0006692018,0.0001002443,0.00009782084,0.0003069358,0.0001265972,0.0002218149,0.0006358633],"category_scores_gemma":[0.001262797,0.0001280821,0.0002634111,0.0001318866,0.0002151897,0.0002700571,0.0001250654,0.0005035923,0.0001286429],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002084599,"about_ca_system_score_gemma":0.0001727619,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004819255,"about_ca_topic_score_gemma":0.000320831,"domain_scores_codex":[0.9996436,0.0001910958,0.00003694725,0.00002864114,0.00006040462,0.00003933558],"domain_scores_gemma":[0.9994247,0.0002209152,0.0001903854,0.00003409316,0.00004540904,0.00008448357],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1378566,0.008186539,0.31351,0.0008764765,0.0009319754,0.003632492,0.001320011,0.004119777,0.3306186,0.000456626,0.001429616,0.1970612],"study_design_scores_gemma":[0.005231627,0.3677957,0.5332803,0.00007463866,0.0006148366,0.006985217,0.0006134749,0.009427935,0.07012673,0.0001816736,0.005621324,0.00004650101],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991524,0.00047412,0.0001845564,0.00001325884,0.000002070042,0.00002320504,0.00003936511,0.000005309315,0.000105804],"genre_scores_gemma":[0.9991997,0.0002125874,0.0003083,0.00003132568,0.000005656862,0.0000326115,0.00009739814,0.000002216667,0.0001102692],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006692018,"threshold_uncertainty_score":0.003176987,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05276655729128442,"score_gpt":0.3449335751139467,"score_spread":0.2921670178226623,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}