{"id":"W2765650816","doi":"10.1038/nm.4419","title":"ADAM10-mediated ephrin-B2 shedding promotes myofibroblast activation and organ fibrosis","year":2017,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Axon Guidance and Neuronal Signaling","field":"Neuroscience","cited_by":170,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; McGill University; University of Toronto; Jewish General Hospital; Université de Montréal","funders":"National Heart, Lung, and Blood Institute","keywords":"Myofibroblast; ADAM10; Fibrosis; Cancer research; Extracellular matrix; Wound healing; Ephrin; Cell biology; Fibroblast; Pathology; Immunology; Signal transduction; Chemistry; Medicine; Biology; Disintegrin; Matrix metalloproteinase; Metalloproteinase; Internal medicine; Cell culture","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004038987,0.0003360653,0.000284646,0.0003240532,0.0002783251,0.0005371927,0.0001786205,0.0005255425,0.002881815],"category_scores_gemma":[0.0002205899,0.0002231817,0.0004707917,0.00009553882,0.0003101767,0.0004275098,0.0003957442,0.001092407,0.000696949],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004536538,"about_ca_system_score_gemma":0.0003292217,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006707486,"about_ca_topic_score_gemma":0.001355979,"domain_scores_codex":[0.9996337,0.00007653105,0.00003086642,0.00004537706,0.00008550204,0.000127949],"domain_scores_gemma":[0.9997483,0.00003554609,0.00005374808,0.00003311725,0.0000279588,0.0001012801],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004042631,0.00008032525,0.0009176625,0.00004389149,0.00001936871,0.0005991852,0.0000293243,0.00008583135,0.9953005,0.0003091805,0.0003117755,0.001898753],"study_design_scores_gemma":[0.00005710426,0.0004961009,0.03216502,0.00001497832,0.00003785178,0.003409864,0.0002043004,0.002112654,0.9574746,0.0004364231,0.00357879,0.00001220169],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927976,0.001396341,0.00254079,0.0003649432,0.00008816491,0.00001970955,0.0002238546,0.0000860912,0.002482576],"genre_scores_gemma":[0.9950186,0.000511037,0.0007666826,0.00006172085,0.00002318694,0.00001324993,0.0002228836,0.00001378329,0.003368807],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002881815,"threshold_uncertainty_score":0.009640694,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02355272138613923,"score_gpt":0.2972293630976504,"score_spread":0.2736766417115111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}