{"id":"W2765655531","doi":"10.1083/jcb.201703168","title":"RECQ-like helicases Sgs1 and BLM regulate R-loop–associated genome instability","year":2017,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":124,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Canada's Michael Smith Genome Sciences Centre; Université Laval; BC Cancer Agency; Centre hospitalier universitaire de Québec; Pacific Centre for Reproductive Medicine","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Cancer Society; Michael Smith Health Research BC; Canadian Institutes of Health Research; U.S. Bureau of Land Management; Institute for Research in Biomedicine","keywords":"Helicase; Genome instability; Biology; Bloom syndrome; DNA replication; Genetics; RecQ helicase; RNA Helicase A; Minichromosome maintenance; Cell biology; DNA repair; DNA; Control of chromosome duplication; Gene; Molecular biology; DNA damage; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001197999,0.0001171133,0.0002273048,0.00003607069,0.0001374406,0.00001799277,0.0004359524,0.000181496,0.00001572476],"category_scores_gemma":[0.0003144401,0.00007804558,0.00007313483,0.0000247982,0.0002463904,0.000005921979,0.0002191609,0.0001674613,0.000002570502],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002171016,"about_ca_system_score_gemma":0.00006389122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003107329,"about_ca_topic_score_gemma":0.00009641378,"domain_scores_codex":[0.9989838,0.0002835084,0.0003118974,0.0001486314,0.00005978675,0.000212379],"domain_scores_gemma":[0.9988186,0.00004259182,0.0004875931,0.0004742111,0.0001141752,0.00006282031],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002004614,0.00005282071,0.001983613,0.000005485776,0.00003234509,0.000006991168,0.00004779109,0.000006677864,0.996754,0.00001777818,0.00002782961,0.0008642437],"study_design_scores_gemma":[0.001724773,0.001502212,0.04582041,0.00002084752,0.0000635469,0.0001824993,0.0001170397,0.00003405358,0.9384697,0.002135144,0.009708227,0.0002215563],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973622,0.001248241,0.00003832798,0.0002873247,0.0002036576,0.00009214001,0.000009106604,0.000002932212,0.0007560738],"genre_scores_gemma":[0.9979776,0.00120694,0.0001579394,0.0001550608,0.00009324578,0.000001144338,0.000005926903,0.00001056921,0.0003916271],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05828427,"threshold_uncertainty_score":0.3182606,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01364857699901655,"score_gpt":0.2511394423165167,"score_spread":0.2374908653175002,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}