{"id":"W2765655531","doi":"10.1083/jcb.201703168","title":"RECQ-like helicases Sgs1 and BLM regulate R-loop–associated genome instability","year":2017,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":124,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Canada's Michael Smith Genome Sciences Centre; Université Laval; BC Cancer Agency; Centre hospitalier universitaire de Québec; Pacific Centre for Reproductive Medicine","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Cancer Society; Michael Smith Health Research BC; Canadian Institutes of Health Research; U.S. Bureau of Land Management; Institute for Research in Biomedicine","keywords":"Helicase; Genome instability; Biology; Bloom syndrome; DNA replication; Genetics; RecQ helicase; RNA Helicase A; Minichromosome maintenance; Cell biology; DNA repair; DNA; Control of chromosome duplication; Gene; Molecular biology; DNA damage; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001492536,0.0004020835,0.000200479,0.0003246834,0.0002030235,0.000431626,0.0002124005,0.0002964307,0.0008319998],"category_scores_gemma":[0.0001706514,0.0001900098,0.0001841494,0.0001369573,0.0003643194,0.000251654,0.0003411153,0.000363029,0.0004709039],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005159026,"about_ca_system_score_gemma":0.000173021,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005815238,"about_ca_topic_score_gemma":0.0007309493,"domain_scores_codex":[0.9998744,0.00002360402,0.000009082065,0.00003170527,0.00002955419,0.00003171621],"domain_scores_gemma":[0.9998336,0.00002512722,0.00006869527,0.00001671406,0.00002004012,0.00003587403],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001062961,0.000007983383,0.0005983987,0.00001434789,0.000002291021,0.00006136822,0.00002021356,0.00008004779,0.9978142,0.000156176,0.00006094491,0.00107775],"study_design_scores_gemma":[0.00002787643,0.0001271849,0.02757276,0.000005426102,0.0000104536,0.0003920585,0.00006713598,0.00184625,0.96719,0.0002914383,0.002462067,0.000007242932],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931883,0.002323658,0.002729448,0.0001401441,0.0000155293,0.00001014093,0.0002019363,0.0002119381,0.001178985],"genre_scores_gemma":[0.9971353,0.0005527336,0.0006124023,0.00002979922,0.000005121005,0.000007988428,0.0002090831,0.00002023445,0.001427321],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008319998,"threshold_uncertainty_score":0.003743172,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01364857699901655,"score_gpt":0.2511394423165167,"score_spread":0.2374908653175002,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}