{"id":"W2765707159","doi":"10.1016/j.celrep.2017.09.092","title":"Fumarate Hydratase Loss Causes Combined Respiratory Chain Defects","year":2017,"lang":"en","type":"article","venue":"Cell Reports","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Cambridge Institute for Medical Research, University of Cambridge; Medical Research Council; Natural Sciences and Engineering Research Council of Canada; Hutchison Whampoa Limited; FP7 People: Marie-Curie Actions; University of Cambridge; Cancer Research UK; Università degli Studi di Padova; Rice University","keywords":"Fumarase; Biogenesis; Fumarate reductase; Citric acid cycle; Respiratory chain; Mitochondrion; Tricarboxylic acid; Biology; Enzyme; Mitochondrial respiratory chain; Biochemistry; Chemistry; Cell biology; Succinate dehydrogenase; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001425521,0.0005797993,0.0003983792,0.000730171,0.0001851759,0.0002636638,0.0002587666,0.0005243772,0.001617435],"category_scores_gemma":[0.000209082,0.0002546034,0.0003935056,0.0003357348,0.0003843005,0.0001681343,0.0004836126,0.0004708309,0.0004130396],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002409611,"about_ca_system_score_gemma":0.0001960579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008438943,"about_ca_topic_score_gemma":0.000862808,"domain_scores_codex":[0.9996998,0.00004293696,0.00003956391,0.00009020352,0.00007705494,0.00005035278],"domain_scores_gemma":[0.9997568,0.00005277318,0.00005953428,0.00003913229,0.00001569613,0.0000760574],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003051295,0.00006042801,0.001752872,0.00004234529,0.0000378784,0.00171038,0.00002824268,0.00009294209,0.9939588,0.0001423077,0.0001213939,0.001747257],"study_design_scores_gemma":[0.00006585033,0.0009412658,0.02553842,0.00001536389,0.0001516067,0.01664842,0.00008832783,0.001532108,0.9496242,0.0001734442,0.005204205,0.00001677049],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947118,0.001009626,0.002305411,0.0000814941,0.00003791281,0.0000367636,0.0005890428,0.0001279998,0.001099918],"genre_scores_gemma":[0.9969807,0.0004377642,0.0006947244,0.0000355481,0.00001184702,0.00002079415,0.0005763289,0.00003567195,0.001206477],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001617435,"threshold_uncertainty_score":0.00541085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01380302679854248,"score_gpt":0.2552390785930923,"score_spread":0.2414360517945498,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}