{"id":"W2765786976","doi":"10.1016/j.sbi.2017.10.013","title":"Complex regulatory mechanisms mediated by the interplay of multiple post-translational modifications","year":2017,"lang":"en","type":"review","venue":"Current Opinion in Structural Biology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":127,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Posttranslational modification; Crosstalk; Protein–protein interaction; Chemistry; Computational biology; Cell biology; Biophysics; Biology; Biochemistry; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002229675,0.000326626,0.0006631313,0.000090248,0.0001326238,0.00001493512,0.0007695055,0.0004363587,0.00006037249],"category_scores_gemma":[0.0002022938,0.0002173502,0.0002872455,0.00006951276,0.0003614732,0.000004232016,0.0001694745,0.0003161513,0.000008187104],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000186275,"about_ca_system_score_gemma":0.0001885028,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000184385,"about_ca_topic_score_gemma":0.00001017839,"domain_scores_codex":[0.9981767,0.0003610929,0.0006564495,0.000460429,0.00009978499,0.0002455238],"domain_scores_gemma":[0.9984837,0.0001186115,0.0006127211,0.0006191944,0.0001105707,0.00005516187],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005236209,0.00004489181,0.0001119691,0.003296752,0.0001785968,8.873109e-8,0.00007542205,0.000002037257,0.01683923,0.006583286,0.002257098,0.9705583],"study_design_scores_gemma":[0.0003195725,0.00009580814,0.0002192454,0.0007556993,0.00002990022,0.00001784757,0.000008777283,0.00004699729,0.0003713181,0.0005468098,0.9973112,0.0002768543],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000369843,0.9921418,0.0002956583,0.00006965449,0.002137616,0.0008128673,0.00410658,0.000009432285,0.00005653889],"genre_scores_gemma":[0.02199215,0.9472817,0.0001597183,0.00001252526,0.0003148112,0.0001674247,0.03002405,0.00002804529,0.00001963843],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9950541,"threshold_uncertainty_score":0.8863286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1085781389183336,"score_gpt":0.3995647273057386,"score_spread":0.290986588387405,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}