{"id":"W2765790396","doi":"10.1016/j.jalz.2017.06.119","title":"[P1–052]: CLINICAL EFFECTS OF TRAMIPROSATE IN APOE4 HOMOZYGOTES WITH MILD TO MODERATE ALZHEIMER'S DISEASE (AD) ARE SUSTAINED OVER 130 WEEKS: RESULTS OF A PHASE 3 EXTENSION STUDY","year":2017,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Amyloidosis: Diagnosis, Treatment, Outcomes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Placebo; Tolerability; Medicine; Internal medicine; Gastroenterology; Analysis of variance; Pharmacokinetics; Repeated measures design; Clinical endpoint; Apolipoprotein E; Phases of clinical research; Clinical trial; Disease; Adverse effect; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001770397,0.001072436,0.001276366,0.0003194898,0.0004751103,0.0005747525,0.000777719,0.001393624,0.004219641],"category_scores_gemma":[0.000711532,0.0003798445,0.001358415,0.0002222423,0.0006091859,0.0006985498,0.000207967,0.002390878,0.001219723],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000313151,"about_ca_system_score_gemma":0.001245872,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001655085,"about_ca_topic_score_gemma":0.001926842,"domain_scores_codex":[0.9996631,0.0001336567,0.00003138184,0.00005748097,0.00004057496,0.00007395048],"domain_scores_gemma":[0.9993538,0.00006292898,0.00008137094,0.00006645446,0.00008777177,0.0003476543],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8097866,0.05983693,0.006902241,0.0003858866,0.001060612,0.000801824,0.000175121,0.0003879757,0.05553941,0.0002330185,0.008821078,0.05606925],"study_design_scores_gemma":[0.4326822,0.5187391,0.03421767,0.000047141,0.0006073943,0.0006473301,0.00004972993,0.0007400714,0.006766878,0.0002330316,0.005216769,0.00005263514],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928045,0.0006789541,0.0003404659,0.0007677187,0.0002645045,0.001038298,0.001390327,0.000103462,0.002611749],"genre_scores_gemma":[0.983319,0.0008497714,0.001540891,0.002116608,0.0006057673,0.001066641,0.004379314,0.00006089225,0.006060962],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004219641,"threshold_uncertainty_score":0.01411617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03153157098133924,"score_gpt":0.3499907333793372,"score_spread":0.3184591623979979,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}