{"id":"W2765799080","doi":"10.1371/journal.ppat.1006667","title":"In vitro characterization of the antivirulence target of Gram-positive pathogens, peptidoglycan O-acetyltransferase A (OatA)","year":2017,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Streptococcal Infections and Treatments","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto; University of Guelph","funders":"Basic Energy Sciences; Office of Science; Biotechnology and Biological Sciences Research Council; Engineering and Physical Sciences Research Council; Canadian Institutes of Health Research; Medical Research Council; Directorate for Biological Sciences; National Institutes of Health; Hospital for Sick Children; Biological and Environmental Research; Canadian Glycomics Network; Government of Ontario; University of Toronto; U.S. Department of Energy","keywords":"Peptidoglycan; Biochemistry; Bacterial cell structure; Oxyanion hole; Biology; Cell wall; Cell envelope; Teichoic acid; Amidase; Microbiology; Enzyme; Bacteria; Active site; Escherichia coli; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008046099,0.0001464821,0.0003417042,0.00008118399,0.0001372864,0.00001160547,0.0001262265,0.00007530201,0.00005748528],"category_scores_gemma":[0.0001109317,0.0001063122,0.0001545414,0.0001408177,0.000174336,0.0001286085,0.00004613035,0.0001151368,0.000007595251],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003685529,"about_ca_system_score_gemma":0.00006674603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007970272,"about_ca_topic_score_gemma":0.00001442118,"domain_scores_codex":[0.9990429,0.00006090741,0.0002883247,0.0002271031,0.0001980258,0.000182782],"domain_scores_gemma":[0.9989592,0.00002557749,0.0002222916,0.0006130649,0.0001297388,0.00005011707],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001117081,0.0006028396,0.2480022,0.00005065059,0.00006274647,0.00002843908,0.000216694,3.759699e-7,0.750338,0.00004033347,0.00000193475,0.000544099],"study_design_scores_gemma":[0.0006740455,0.0001013776,0.4309526,0.0001465903,0.00008651514,0.000008857995,0.00001868178,0.00006952474,0.5678485,0.00002420297,0.00001560709,0.00005347266],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971975,0.00001391762,0.0001139869,0.0002562289,0.0001077959,0.0007324115,0.00115756,0.00001138492,0.000409227],"genre_scores_gemma":[0.9992031,0.0000473107,0.0003766301,0.00005346107,0.00004269739,0.00005694548,0.00008771462,0.00001788365,0.0001141824],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1829504,"threshold_uncertainty_score":0.4335285,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01916257775228693,"score_gpt":0.2650846503922962,"score_spread":0.2459220726400093,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}