{"id":"W2765799080","doi":"10.1371/journal.ppat.1006667","title":"In vitro characterization of the antivirulence target of Gram-positive pathogens, peptidoglycan O-acetyltransferase A (OatA)","year":2017,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Streptococcal Infections and Treatments","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto; University of Guelph","funders":"Basic Energy Sciences; Office of Science; Biotechnology and Biological Sciences Research Council; Engineering and Physical Sciences Research Council; Canadian Institutes of Health Research; Medical Research Council; Directorate for Biological Sciences; National Institutes of Health; Hospital for Sick Children; Biological and Environmental Research; Canadian Glycomics Network; Government of Ontario; University of Toronto; U.S. Department of Energy","keywords":"Peptidoglycan; Biochemistry; Bacterial cell structure; Oxyanion hole; Biology; Cell wall; Cell envelope; Teichoic acid; Amidase; Microbiology; Enzyme; Bacteria; Active site; Escherichia coli; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003885709,0.0006852023,0.0004043681,0.0002037171,0.0001652981,0.0004792975,0.0002778791,0.0002887551,0.0005183818],"category_scores_gemma":[0.0004934427,0.0001618968,0.0003685141,0.0002946572,0.0001546212,0.0001938553,0.0002723503,0.0007465051,0.0007050235],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000329969,"about_ca_system_score_gemma":0.0003010557,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001350353,"about_ca_topic_score_gemma":0.001528442,"domain_scores_codex":[0.9995289,0.0001224457,0.00003910804,0.00005958085,0.0001661969,0.00008380671],"domain_scores_gemma":[0.9995719,0.0001702235,0.00005390912,0.00005752239,0.0000886391,0.00005785761],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005034539,0.00006528949,0.0002440396,0.00003912697,0.000006631021,0.00002503053,0.00001403399,0.0001800034,0.9983984,0.00006089452,0.00003359706,0.0008825306],"study_design_scores_gemma":[0.000007395982,0.0004011126,0.002712275,0.00000731308,0.00002019112,0.0002411039,0.00002047275,0.001664402,0.9913909,0.00005341917,0.003474112,0.000007199131],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9789725,0.006276438,0.01032425,0.0001210762,0.0001189306,0.0000747727,0.001514362,0.00005600542,0.002541601],"genre_scores_gemma":[0.9715357,0.002595924,0.01218157,0.0001016963,0.00005812124,0.00005340835,0.00935494,0.00004603235,0.004072526],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001350353,"threshold_uncertainty_score":0.002684951,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01916257775228693,"score_gpt":0.2650846503922962,"score_spread":0.2459220726400093,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}