{"id":"W2765801571","doi":"10.1158/1538-8514.synthleth-pr01","title":"Abstract PR01: A functional variomic chemi-genetic screen in C. elegans identifies new synthetic lethal interactions with PARP inhibition that are conserved from worm to human","year":2017,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Biology; Caenorhabditis elegans; Synthetic lethality; Genetics; Olaparib; Model organism; Gene; Genetic screen; Mutation; PARP inhibitor; DNA repair; Poly ADP ribose polymerase; Homologous recombination; Polymerase; Mutant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002454493,0.0008037271,0.0003624408,0.0005685496,0.0003460574,0.0003304749,0.0005544001,0.0005476207,0.002567001],"category_scores_gemma":[0.0001830134,0.000252467,0.0004963938,0.0002491465,0.0002976005,0.0001504265,0.000293003,0.0006124951,0.0007072537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004359101,"about_ca_system_score_gemma":0.000368642,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00232217,"about_ca_topic_score_gemma":0.004238954,"domain_scores_codex":[0.9997099,0.0000241495,0.00003134956,0.00007303493,0.0001201443,0.00004141475],"domain_scores_gemma":[0.9997533,0.00005363396,0.00007763152,0.00002204417,0.00003942599,0.0000540457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007217666,0.00003673865,0.0002228315,0.00003536551,0.000009853838,0.0001030197,0.000004974816,0.00009773886,0.9980111,0.00005264788,0.0001340728,0.001219426],"study_design_scores_gemma":[0.00003101513,0.0005830195,0.007760964,0.00001583014,0.00004466972,0.0005601681,0.00002303096,0.001455338,0.9855821,0.00002564858,0.003901767,0.00001654726],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9765637,0.00100736,0.008793386,0.000217507,0.0000730412,0.0003771739,0.007538246,0.0006641784,0.00476547],"genre_scores_gemma":[0.9642281,0.0007567132,0.01542178,0.0002422869,0.0000114574,0.0002285626,0.007203736,0.0002917645,0.01161553],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002567001,"threshold_uncertainty_score":0.00858742,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04231862433460418,"score_gpt":0.2832813918169053,"score_spread":0.2409627674823011,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}