{"id":"W2765838352","doi":"10.1038/s41467-017-01125-y","title":"Modelling Torsade de Pointes arrhythmias in vitro in 3D human iPS cell-engineered heart tissue","year":2017,"lang":"en","type":"article","venue":"Nature Communications","topic":"Neuroscience and Neural Engineering","field":"Neuroscience","cited_by":108,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Toronto","keywords":"Induced pluripotent stem cell; Myocyte; In vitro; Spiral wave; Cell culture; Extracellular; Drug discovery; Pharmacology; Cell biology; Medicine; Chemistry; Embryonic stem cell; Biology; Spiral (railway); Bioinformatics; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003286228,0.000361733,0.0003379797,0.0003450594,0.0001623886,0.0007762312,0.0005854978,0.0007775868,0.000521316],"category_scores_gemma":[0.0003198076,0.0003099544,0.0005952757,0.0002646692,0.0003399751,0.0002841317,0.0003674235,0.0004036285,0.0002329663],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004473551,"about_ca_system_score_gemma":0.0003742092,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002199017,"about_ca_topic_score_gemma":0.002346708,"domain_scores_codex":[0.9998546,0.00001837,0.00001456622,0.00002731672,0.00006819663,0.00001701647],"domain_scores_gemma":[0.9998145,0.00006709299,0.00004539557,0.0000279765,0.0000291745,0.00001583851],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008459324,0.00007818793,0.002495315,0.0002718841,0.00006285579,0.0007017888,0.0002413204,0.504723,0.4815136,0.002324091,0.0002401548,0.007263174],"study_design_scores_gemma":[0.00002420728,0.000204929,0.003928516,0.00005140369,0.00008760464,0.0004842195,0.0001186069,0.7803231,0.206984,0.00126715,0.006463009,0.00006324613],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7773575,0.001676998,0.2115539,0.000152814,0.0001033382,0.0001733375,0.001664548,0.0004075966,0.0069101],"genre_scores_gemma":[0.9054145,0.001671053,0.08956629,0.00007905859,0.00001376287,0.0002223472,0.001176555,0.00007411344,0.001782288],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002199017,"threshold_uncertainty_score":0.004372418,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05451712885353465,"score_gpt":0.3294827096048545,"score_spread":0.2749655807513198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}