{"id":"W2765838352","doi":"10.1038/s41467-017-01125-y","title":"Modelling Torsade de Pointes arrhythmias in vitro in 3D human iPS cell-engineered heart tissue","year":2017,"lang":"en","type":"article","venue":"Nature Communications","topic":"Neuroscience and Neural Engineering","field":"Neuroscience","cited_by":108,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Toronto","keywords":"Induced pluripotent stem cell; Myocyte; In vitro; Spiral wave; Cell culture; Extracellular; Drug discovery; Pharmacology; Cell biology; Medicine; Chemistry; Embryonic stem cell; Biology; Spiral (railway); Bioinformatics; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002289398,0.0001456805,0.0001699508,0.0002178911,0.0005209441,0.0001425701,0.001743288,0.0001520647,0.000003690562],"category_scores_gemma":[0.0005286853,0.0001552171,0.00003981649,0.0002679674,0.000134791,0.0004273803,0.0003646808,0.001422642,0.00001255329],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007982498,"about_ca_system_score_gemma":0.00003647792,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001024324,"about_ca_topic_score_gemma":0.0001082871,"domain_scores_codex":[0.9988636,0.00009702614,0.0002293748,0.0002971132,0.0001582182,0.0003546925],"domain_scores_gemma":[0.9976813,0.0002820941,0.00007556838,0.001866968,0.00001706931,0.00007701537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000004249073,0.0000555341,0.0001954148,0.000006670915,2.231288e-7,0.00001455272,0.0001918846,0.009610706,0.9883805,0.001399362,0.00003958896,0.000101301],"study_design_scores_gemma":[0.0002515489,0.00001671969,0.001518741,0.00004266111,0.000002266926,0.00002530923,0.0000187383,0.1701168,0.8230808,0.0002453885,0.004497424,0.0001835846],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916491,0.0005670228,0.0003976945,0.003926313,0.0002312606,0.0002896329,0.00001273223,0.0001112791,0.002814977],"genre_scores_gemma":[0.9955637,0.0001847709,0.003550597,0.0004279125,0.00003668762,0.00003351322,0.000003023718,0.00002271411,0.0001771075],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1652997,"threshold_uncertainty_score":0.6329569,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05451712885353465,"score_gpt":0.3294827096048545,"score_spread":0.2749655807513198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}