{"id":"W2765841813","doi":"10.3389/fncel.2017.00333","title":"Down-regulation of NTPDase2 and ADP-sensitive P2 Purinoceptors Correlate with Severity of Symptoms during Experimental Autoimmune Encephalomyelitis","year":2017,"lang":"en","type":"article","venue":"Frontiers in Cellular Neuroscience","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja","keywords":"Glial fibrillary acidic protein; Experimental autoimmune encephalomyelitis; Receptor; Purinergic receptor; Downregulation and upregulation; Purinergic signalling; Immunology; Encephalomyelitis; Chemistry; Biology; Molecular biology; Cell biology; Adenosine receptor; Multiple sclerosis; Biochemistry; Agonist; Immunohistochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000104786,0.0001289093,0.0001854592,0.00006013237,0.0001567023,0.00002220374,0.0002220869,0.00007076299,0.000003233462],"category_scores_gemma":[0.00004160281,0.0001226562,0.00003626938,0.00006857853,0.000610697,0.00002768659,0.0001612713,0.00007401805,1.155003e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000111774,"about_ca_system_score_gemma":0.00003584879,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005864063,"about_ca_topic_score_gemma":9.552373e-7,"domain_scores_codex":[0.9990489,0.00003969716,0.0002031411,0.0003576791,0.0001663841,0.0001841625],"domain_scores_gemma":[0.9993252,0.000004266409,0.000240198,0.0003424167,0.00004084184,0.00004709391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009721977,0.00003627443,0.05405777,0.00002026632,0.000005263879,0.00001344639,0.0001732323,0.0003233302,0.9450163,0.00001201247,0.00002831303,0.0002165855],"study_design_scores_gemma":[0.0004226126,0.0001532528,0.3491153,0.00003852845,0.000005747112,0.00001496257,0.000108474,0.0009088924,0.6490751,0.00000773739,0.00004954636,0.0000999051],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954726,0.0009622963,0.002943324,0.0000130757,0.0003299252,0.0001283862,0.00000956597,0.000004280846,0.0001365573],"genre_scores_gemma":[0.9989575,0.00006846579,0.0007018793,0.000010144,0.00002861513,0.000003831144,0.000007465288,0.00001018087,0.0002118933],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2959412,"threshold_uncertainty_score":0.5001776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005179304617296395,"score_gpt":0.2104975733768698,"score_spread":0.2053182687595733,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}