{"id":"W2765890360","doi":"10.1186/s13072-017-0156-y","title":"NuA4 histone acetyltransferase activity is required for H4 acetylation on a dosage-compensated monosomic chromosome that confers resistance to fungal toxins","year":2017,"lang":"en","type":"article","venue":"Epigenetics & Chromatin","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; National Institutes of Health; University of Toronto; National Institute of General Medical Sciences; University of Rochester","keywords":"Biology; Dosage compensation; Genetics; Histone H4; Chromosome; Acetylation; Gene; Histone acetyltransferase; Ploidy; Gene dosage; Acetyltransferase; Histone; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009273117,0.0003901418,0.0002149865,0.0003165772,0.0001964962,0.0002611789,0.0003641258,0.0002862053,0.001709803],"category_scores_gemma":[0.0001910079,0.0002107691,0.0002563054,0.0001795699,0.0002940026,0.0001364394,0.0003151378,0.0003400878,0.0003789356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005291334,"about_ca_system_score_gemma":0.0002798863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001528033,"about_ca_topic_score_gemma":0.002716464,"domain_scores_codex":[0.9998481,0.00001188701,0.00001506213,0.00004692552,0.00005016,0.00002782258],"domain_scores_gemma":[0.9997277,0.0000486606,0.00009956561,0.00003208974,0.00001774103,0.00007428465],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000621471,0.000004870476,0.0002259593,0.00001288296,0.000002801636,0.00002795611,0.000004279872,0.00002487441,0.9993309,0.00003110021,0.000009240847,0.0002629245],"study_design_scores_gemma":[0.000009137587,0.00008439679,0.02486143,0.000004782762,0.0000132492,0.0002060932,0.00002854051,0.001051373,0.972932,0.000040345,0.0007629586,0.000005671557],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966428,0.000375435,0.001876646,0.00003790983,0.00001529439,0.00001001334,0.0005119319,0.00007919253,0.0004508072],"genre_scores_gemma":[0.9969951,0.0001002829,0.001085527,0.00001902141,0.000003655278,0.00001152735,0.0007164401,0.00002299169,0.001045425],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001709803,"threshold_uncertainty_score":0.005719841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05666073123605199,"score_gpt":0.350820470096309,"score_spread":0.294159738860257,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}