{"id":"W2765894939","doi":"10.1021/acschembio.7b00797","title":"Insights into Interactions of Mycobacteria with the Host Innate Immune System from a Novel Array of Synthetic Mycobacterial Glycans","year":2017,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Glycomics Centre; University of Alberta","funders":"Biotechnology and Biological Sciences Research Council; Canadian Institutes of Health Research; Wellcome; Alberta Glycomics Centre; Wellcome Trust; Bill and Melinda Gates Foundation","keywords":"Glycan; Innate immune system; DC-SIGN; Mannose receptor; Biology; Pattern recognition receptor; Receptor; Mannose; Lipoarabinomannan; Glycosylation; Immune receptor; Glycolipid; Cell biology; Glycobiology; Endocytic cycle; Immune system; Mycobacterium tuberculosis; Biochemistry; Glycoprotein; Dendritic cell; Immunology; Endocytosis; Macrophage; Tuberculosis; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001697714,0.0002716263,0.0001891194,0.000172932,0.00006706794,0.0003561246,0.0001463699,0.0002566896,0.0003145162],"category_scores_gemma":[0.0000905026,0.0001008911,0.0002580034,0.00009045636,0.0001662102,0.0003101506,0.000186612,0.0003565659,0.0001277992],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001799491,"about_ca_system_score_gemma":0.0001041297,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009493183,"about_ca_topic_score_gemma":0.0001733019,"domain_scores_codex":[0.9999285,0.00001634107,0.000004624534,0.000008817602,0.00002426996,0.0000173614],"domain_scores_gemma":[0.9999775,0.000005282922,0.000004481647,0.00000329541,0.000003699963,0.000005751904],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007037568,0.00001151512,0.0003628031,0.00009987923,0.000005820569,0.00009262194,0.00001879831,0.0001520029,0.995077,0.0003069902,0.00001623391,0.003785988],"study_design_scores_gemma":[0.00003301713,0.001461197,0.01683653,0.00009249036,0.00008002741,0.002465869,0.0001694634,0.003427571,0.9564017,0.001162585,0.01785062,0.00001879186],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.96873,0.02111835,0.007166558,0.0002159341,0.00003504541,0.00002007164,0.00009982365,0.00003838743,0.002575958],"genre_scores_gemma":[0.9750757,0.01383844,0.009706648,0.0002476149,0.00003580376,0.00001855623,0.0001839572,0.000008277406,0.0008850203],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003561246,"threshold_uncertainty_score":0.00130558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01117458020186511,"score_gpt":0.2636289524040991,"score_spread":0.2524543722022339,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}