{"id":"W2765894939","doi":"10.1021/acschembio.7b00797","title":"Insights into Interactions of Mycobacteria with the Host Innate Immune System from a Novel Array of Synthetic Mycobacterial Glycans","year":2017,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Glycomics Centre; University of Alberta","funders":"Biotechnology and Biological Sciences Research Council; Canadian Institutes of Health Research; Wellcome; Alberta Glycomics Centre; Wellcome Trust; Bill and Melinda Gates Foundation","keywords":"Glycan; Innate immune system; DC-SIGN; Mannose receptor; Biology; Pattern recognition receptor; Receptor; Mannose; Lipoarabinomannan; Glycosylation; Immune receptor; Glycolipid; Cell biology; Glycobiology; Endocytic cycle; Immune system; Mycobacterium tuberculosis; Biochemistry; Glycoprotein; Dendritic cell; Immunology; Endocytosis; Macrophage; Tuberculosis; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009550212,0.0001654253,0.0003007268,0.00003875119,0.0001353016,0.00002637387,0.0006466832,0.000206011,0.00003303712],"category_scores_gemma":[0.0002281311,0.0001045937,0.00008612958,0.00005434673,0.0006436824,0.000008906275,0.0002601891,0.0001619541,0.000008605891],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002117059,"about_ca_system_score_gemma":0.00008325224,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006594182,"about_ca_topic_score_gemma":0.0001327466,"domain_scores_codex":[0.9989849,0.00007213205,0.0003233325,0.0003255798,0.0001016567,0.0001924458],"domain_scores_gemma":[0.9983976,0.00006023714,0.0003632288,0.0009015115,0.0002167038,0.00006069758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007054132,0.00007131316,0.0004571247,0.00002857125,0.0001406627,8.2792e-7,0.0001007233,3.974434e-7,0.9976489,0.0004649718,0.000017639,0.0003634585],"study_design_scores_gemma":[0.0008696002,0.0002103717,0.003504151,0.00005784292,0.00002504961,0.00000941421,0.00010313,0.000008583948,0.9875332,0.00003916868,0.007517496,0.0001220459],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973944,0.0001212205,0.000876083,0.0004381734,0.0002078356,0.000231382,0.00009523309,0.000007828738,0.0006278686],"genre_scores_gemma":[0.99902,0.00002686556,0.000405074,0.00002200997,0.0001927334,0.00004395336,0.0002247739,0.00001629111,0.00004830861],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01011575,"threshold_uncertainty_score":0.4265207,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01117458020186511,"score_gpt":0.2636289524040991,"score_spread":0.2524543722022339,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}