{"id":"W2765899161","doi":"10.1016/j.celrep.2017.10.015","title":"A Targetable EGFR-Dependent Tumor-Initiating Program in Breast Cancer","year":2017,"lang":"en","type":"article","venue":"Cell Reports","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill Genome Centre; McGill University and Génome Québec Innovation Centre; Jewish General Hospital; McGill University; McGill University Health Centre","funders":"Fonds de Recherche du Québec - Santé; Genome Canada; Canadian Institutes of Health Research; McGill University Health Centre; Stand Up To Cancer; McGill University","keywords":"Gefitinib; Epidermal growth factor receptor; Cancer research; Breast cancer; Triple-negative breast cancer; EGFR inhibitors; Biology; Metastatic breast cancer; Cancer; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003307205,0.0001558505,0.0003527488,0.00006636517,0.0001576313,0.00009169649,0.00008004969,0.0000502886,0.000677245],"category_scores_gemma":[0.00004961244,0.0001365116,0.000102932,0.00006234442,0.00005298395,0.0001281311,0.00008642209,0.0002067276,0.00001298312],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001655942,"about_ca_system_score_gemma":0.0003412509,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00441014,"about_ca_topic_score_gemma":0.0004530996,"domain_scores_codex":[0.998495,0.00001327809,0.0004060029,0.0003972536,0.0002987638,0.0003897022],"domain_scores_gemma":[0.9985371,0.000008855888,0.0004371575,0.0007391775,0.00009336895,0.000184327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001027593,0.0006926889,0.848053,0.0003925263,0.00005077722,0.01546388,0.0002382072,0.00003087208,0.01690922,0.000006974008,0.002934121,0.115125],"study_design_scores_gemma":[0.003616175,0.0002151128,0.7187032,0.0009997246,0.0003709978,0.004619686,0.0003795559,0.0002250768,0.1132989,0.0001595295,0.1566553,0.0007567593],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.908608,0.001551969,0.000008565787,0.0006868539,0.0008162166,0.0007557816,0.00001260688,0.0000774924,0.08748253],"genre_scores_gemma":[0.9942985,0.0002248917,0.0007885577,0.0002240617,0.0003070505,0.0001889151,0.0000103905,0.00003246168,0.003925171],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1537212,"threshold_uncertainty_score":0.7415358,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02193804124419668,"score_gpt":0.3111161914840679,"score_spread":0.2891781502398713,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}