{"id":"W2765953128","doi":"10.1007/s10534-017-0058-2","title":"The six metal binding domains in human copper transporter, ATP7B: molecular biophysics and disease-causing mutations","year":2017,"lang":"en","type":"review","venue":"BioMetals","topic":"Trace Elements in Health","field":"Nursing","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fondation Chalmers; Umeå Universitet; Vetenskapsrådet; Knut och Alice Wallenbergs Stiftelse","keywords":"Missense mutation; Point mutation; Mutant; Biology; Biochemistry; Transport protein; Mutation; Chemistry; Transporter; Genetics; Cell biology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts"],"consensus_categories":[],"category_scores_codex":[0.0008618361,0.0005725352,0.001391348,0.0006367508,0.001778388,0.0003005899,0.0004602383,0.0002269406,0.00001045263],"category_scores_gemma":[0.0001487707,0.0004322002,0.0004867585,0.0006054326,0.0004468783,0.0002505607,0.0001046048,0.0004396404,0.00001934368],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002705581,"about_ca_system_score_gemma":0.0001831723,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006996631,"about_ca_topic_score_gemma":0.00006144139,"domain_scores_codex":[0.9966902,0.0004094685,0.001058078,0.0006942444,0.0004591538,0.0006889055],"domain_scores_gemma":[0.9975584,0.0003294649,0.0008083077,0.000970775,0.00003963754,0.0002934193],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001961493,0.0002262742,0.0001493092,0.01076032,0.0005792399,0.0002582447,0.0003785817,0.000001402754,0.0006599926,0.001401181,0.00007765934,0.9854882],"study_design_scores_gemma":[0.0006127479,0.00007642934,0.0003898974,0.007597586,0.002889124,0.00002359486,0.00005119278,0.000005250251,0.00004664722,0.000686915,0.9868456,0.0007750313],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01201737,0.9841607,0.00003360126,0.0001993049,0.001089078,0.001857776,0.0004870783,0.00007051042,0.00008456314],"genre_scores_gemma":[0.0243986,0.9737329,0.0003989954,0.00004871866,0.0002410591,0.0002420063,0.0005959754,0.0001994276,0.0001422633],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9867679,"threshold_uncertainty_score":0.999813,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.114521630549428,"score_gpt":0.4253736670765981,"score_spread":0.31085203652717,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}